{"created":"2023-05-15T14:47:09.949420+00:00","id":64680,"links":{},"metadata":{"_buckets":{"deposit":"902ad365-ded8-44d6-95a5-3679891640d9"},"_deposit":{"created_by":1,"id":"64680","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64680"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064680","sets":["10:29"]},"author_link":["637421","637426","637429","637431","637427","637419","637418","637424","637417","637422","637423","637420","637425","637430","637428"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-07-21","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】遠隔転移のない局所進行子宮頸部腺癌に対する重粒子線治療の第I/II相臨床試験の有効性と安全性を評価する。【方法】全骨盤12回（36.0GyE）+拡大局所4回および局所4回（26.4GyE-36.4GyE、５段階にわけて増量）の照射（総線量：62.4-74.4GyE）が行われた。【成績】1998年4月-2010年2月に61症例が登録され、58症例で解析がなされた（3例は不適格症例）。年齢は28-85歳（中央値59歳）、進行期はIIｂ:20例、IIIｂ:35例、IVa:3例、組織型は腺癌:48例、腺扁平上皮癌:10例、腫瘍径は3.0-11.8 cm（中央値5.5 cm）であった。骨盤内リンパ節転移は27例に認めた。全症例の追跡期間中央値は31か月であった。23例にG1-G3の急性期有害事象が出現したが、全例予定通りに治療が完遂された。晩期有害事象としては、G1-G2（直腸/S状結腸:12例、膀胱:10例、小腸:6例）が19例に認められた。G4の直腸出血（手術により治癒）が初期の症例で1例に認められたため、途中より照射法を改良した。それ以後、直腸のG3以上の有害事象は出現しなかった。局所再発が27例(46.6%)にみられ、そのうち10例に救済手術が行われた。遠隔転移は36例(62.1%)で認められた。3年局所制御率は53.4%、3年全生存率は53.4%であった。救済手術も含めた3年局所制御率は62.9%であった。【結論】局所進行子宮頸部腺癌に対する重粒子線治療は、安全かつ有効な治療法と考えられる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第52回　日本婦人科腫瘍学会学術講演会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"若月, 優"}],"nameIdentifiers":[{"nameIdentifier":"637417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 真吾"}],"nameIdentifiers":[{"nameIdentifier":"637418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野, 達也"}],"nameIdentifiers":[{"nameIdentifier":"637419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"唐澤, 久美子"}],"nameIdentifiers":[{"nameIdentifier":"637420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 謙"}],"nameIdentifiers":[{"nameIdentifier":"637421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清原, 浩樹"}],"nameIdentifiers":[{"nameIdentifier":"637422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野, 隆史"}],"nameIdentifiers":[{"nameIdentifier":"637423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 正"}],"nameIdentifiers":[{"nameIdentifier":"637424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生水, 真紀夫"}],"nameIdentifiers":[{"nameIdentifier":"637425","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"若月 優","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637426","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 眞吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637427","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"唐澤 久美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637428","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 謙","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637429","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生水 真紀夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637431","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"局所進行子宮頸部腺癌に対する重粒子線治療の有効性と安全性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"局所進行子宮頸部腺癌に対する重粒子線治療の有効性と安全性"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-07-25"},"publish_date":"2012-07-25","publish_status":"0","recid":"64680","relation_version_is_last":true,"title":["局所進行子宮頸部腺癌に対する重粒子線治療の有効性と安全性"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:08:51.878724+00:00"}