{"created":"2023-05-15T14:47:09.065722+00:00","id":64660,"links":{},"metadata":{"_buckets":{"deposit":"f85e83e0-9d7b-4f9a-b7fb-17d572eabc2e"},"_deposit":{"created_by":1,"id":"64660","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64660"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064660","sets":["10:29"]},"author_link":["637219","637214","637220","637215","637221","637218","637216","637222","637217"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-07-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"これまでに，ポリイオンコンプレックス型中空ナノ粒子（PICsome）に，蛍光色素を導入することで腫瘍への集積動態の可視化に成功した．本発表では，この長い血中半減期を有するPICsomeにカルボキシル・デキストランで被覆した超常磁性酸化鉄微粒子を内包させることで，MRIによるin vivoイメージングに適用した．マウス由来大腸がんColon26皮下腫瘍マウスに対し，蛍光色素に加えMR陰性造影剤のResovist（富士フィルムRIファーマ）を内包したPICsomeを投与し，腫瘍への集積を動物用水平型7テスラMR装置（Kobelco+Bruker Biospin）を用いて観察した．T2強調画像において，投与3時間後で腫瘍の一部で信号が低下し始め，6，24時間後でその範囲が拡大し顕著な信号変化を示した．in vivo蛍光画像においても腫瘍への集積を観察できたことから，MR陰性造影剤を含むPICsomeが腫瘍へ集積したと考えられた．","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第28回日本ＤＤＳ学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"國領, 大介"}],"nameIdentifiers":[{"nameIdentifier":"637214","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"狩野, 光伸"}],"nameIdentifiers":[{"nameIdentifier":"637215","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"637216","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木, 伊知男"}],"nameIdentifiers":[{"nameIdentifier":"637217","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"637218","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"國領 大介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637219","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"狩野  光伸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637220","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637221","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"637222","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"超常磁性酸化鉄微粒子を内包したポリイオンコンプレックス型中空ナノ粒子PICsomeを用いたin vivo MRイメージング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"超常磁性酸化鉄微粒子を内包したポリイオンコンプレックス型中空ナノ粒子PICsomeを用いたin vivo MRイメージング"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-07-06"},"publish_date":"2012-07-06","publish_status":"0","recid":"64660","relation_version_is_last":true,"title":["超常磁性酸化鉄微粒子を内包したポリイオンコンプレックス型中空ナノ粒子PICsomeを用いたin vivo MRイメージング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:09:05.471789+00:00"}