{"created":"2023-05-15T14:47:06.783915+00:00","id":64609,"links":{},"metadata":{"_buckets":{"deposit":"16cbcf86-9a3e-467d-9829-7e479f9ee9bc"},"_deposit":{"created_by":1,"id":"64609","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64609"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064609","sets":["10:29"]},"author_link":["636729","636720","636731","636721","636728","636725","636722","636727","636723","636730","636726","636724"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"統合失調症患者の死後脳研究においてD<sub>1</sub>とD<sub>2</sub>受容体のバラン\nスの変化が報告されている。従って、健常者脳において、D<sub>1</sub>とD<sub>2</\nsub>受容体濃度を測定し、その比の分布をデータベース化する事は、神経精神疾患の\n病態理解に役立つものと考える。本研究の目的は、同一健常被験者においてPETを用\nいて線条体内外のD<sub>1</sub>とD<sub>2</sub>受容体濃度を測定し、D<sub>1</sub\n/D<sub>2</sub>比の分布を評価する事である。＜方法＞９名の健常男性に<sup>11</\nsup>C-SCH23390、<sup>11</sup>C-raclopride、<sup>11</sup>C-FLB457を用いた計３\n回のPETスキャンを施行した。小脳を参照領域としたSimplified reference tissue m\nodel を用いて各受容体結合能を算出し、線条体および線条体外についてD<sub>1</su\nb>/D<sub>2</sub>比の画像を作成した。＜結果＞線条体では、sensorimotor striatu\nmのD<sub>1</sub>/D<sub>2</sub>比はassociative striatumやlimbic striatumに比\nべて有意に低かった（One-way ANOVA, p＜0.005）。線条体外では、D<sub>1</sub>/D\n<sub>2</sub>比は線条体に比し約３−８倍高値であった。線条体外のD<sub>1</sub>/\nD<sub>2</sub>比は領域により有意に異なり、側頭葉において他の皮質領域に比べて\n低く、内側側頭葉において最も低かった（One-way ANOVA, p＜0.0001）。＜考察＞線\n条体においてはD<sub>2</sub>受容体が豊富なextrastrisomal matrixが感覚運動系に\n関連するという知見と一致した。線条体外では側頭葉でD<sub>2</sub>受容体が多い\nという死後脳研究と一致した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第23回日本脳循環代謝学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木村, 泰之"}],"nameIdentifiers":[{"nameIdentifier":"636720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"636721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原, 広臨"}],"nameIdentifiers":[{"nameIdentifier":"636722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高, 文聰"}],"nameIdentifiers":[{"nameIdentifier":"636723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"636724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"636725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原 広臨","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636731","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"線条体、線条体外におけるドーパミンD1、D2レセプターの分布比の健常者データベー ス","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"線条体、線条体外におけるドーパミンD1、D2レセプターの分布比の健常者データベー ス"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-06-07"},"publish_date":"2012-06-07","publish_status":"0","recid":"64609","relation_version_is_last":true,"title":["線条体、線条体外におけるドーパミンD1、D2レセプターの分布比の健常者データベー ス"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:09:40.501890+00:00"}