{"created":"2023-05-15T14:47:03.875715+00:00","id":64543,"links":{},"metadata":{"_buckets":{"deposit":"cef0b04f-126e-4535-a451-0d93ee5a7d8f"},"_deposit":{"created_by":1,"id":"64543","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64543"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064543","sets":["10:29"]},"author_link":["636206","636211","636217","636208","636213","636218","636205","636212","636207","636209","636215","636216","636210","636214"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-10-29","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"東北大学で開発されたアミロイド測定用トレーサー[F-18]FACTを用いて脳内アミロイド蓄積を定量的に評価した。健常者6名、アルツハイマー病(AD)患者6名を対象に[F-18]FACTおよび[C-11]PIBによるPET検査を同日に施行し、MRIを用いた部分容積効果補正により単位灰白質量当たりのSUVを求め、小脳を参照領域として大脳皮質領域におけるSUVRを計算した。両トレーサー共にADにおいてSUVRは有意に高値であった。AD患者における両トレーサーの脳内分布には違いがみられ、後頭葉、海馬傍回では[C-11]PIBの集積が相対的に低値、前頭葉、頭頂葉では[C-11]PIBの集積が相対的に高値であった。 [F-18]FACTはneuritic plaqueに主に結合し、[C-11]PIBはneuritic plaqueとdiffuse plaqueの両方に結合するが、前頭葉に比べ後頭葉ではdiffuse plaqueが相対的に少ないことも病理学的に示されており、両トレーサーの脳内分布の差異はそれぞれのトレーサーが反映する脳病理変化の違いを反映している可能性がある。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第51回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"636205","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"636206","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"636207","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"636208","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高, 文聰"}],"nameIdentifiers":[{"nameIdentifier":"636209","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"636210","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡村, 信行"}],"nameIdentifiers":[{"nameIdentifier":"636211","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷内, 一彦"}],"nameIdentifiers":[{"nameIdentifier":"636212","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636213","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636214","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636215","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636216","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636217","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"636218","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[F-18]FACTによる脳内アミロイド蓄積の評価：[C-11]PIBとの比較","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[F-18]FACTによる脳内アミロイド蓄積の評価：[C-11]PIBとの比較"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-03-26"},"publish_date":"2012-03-26","publish_status":"0","recid":"64543","relation_version_is_last":true,"title":["[F-18]FACTによる脳内アミロイド蓄積の評価：[C-11]PIBとの比較"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:10:25.609974+00:00"}