{"created":"2023-05-15T14:47:02.415493+00:00","id":64514,"links":{},"metadata":{"_buckets":{"deposit":"752ce459-6f66-4b7e-a314-c22f5d0a53ae"},"_deposit":{"created_by":1,"id":"64514","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64514"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064514","sets":["10:29"]},"author_link":["635949","635942","635939","635950","635953","635957","635954","635958","635948","635951","635945","635940","635944","635952","635955","635941","635946","635943","635947","635956"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-10-29","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】健常高齢者（NC）、軽度認知障害(MCI),　アルツハイマー病(AD)におけるア\nミロイド沈着の変化を測定する。【対象】NC 11例、MCI 10例、AD8例を対象として約\n2年間の間隔をおいて2回の[11C]PIB PETを行った。NC 7例ではさらに4年目に3回目の\n[11C]PIB PETを行った。【方法】 [11C]PIBを静脈投与し、HR+スキャナ\nーにて90分間撮像した。小脳皮質を参照領域としてLogan解析を行い、大脳皮質の分\n布容積比(DVR)を求めた。【結果】被験者全体において2年間でDVR が0.048単位 (1.8\n%/年）の増加がみられた（p ＜ 0.02, Paired t-test）。健常者、MCI, AD の3群に\nおいてDVRの2年間の増加に有意差はなかった。3回目の測定を行った健常者7名におい\nてDVRは4年間で0.06 (1.4％/年）のDVRの増加がみられた。【結論】NC、MCI, ADにお\nいて、脳内アミロイド沈着は増加していくことが確認された。　","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第51回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"635939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 崇明"}],"nameIdentifiers":[{"nameIdentifier":"635940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"635941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"635942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 典子"}],"nameIdentifiers":[{"nameIdentifier":"635943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 康一"}],"nameIdentifiers":[{"nameIdentifier":"635944","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"635945","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"635946","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"635947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"635948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 崇明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 康一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635957","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635958","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]PIB PETの縦断的研究　−健常高齢者、軽度認知障害、アルツハイマー病における変化―","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]PIB PETの縦断的研究　−健常高齢者、軽度認知障害、アルツハイマー病における変化―"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-02-23"},"publish_date":"2012-02-23","publish_status":"0","recid":"64514","relation_version_is_last":true,"title":["[11C]PIB PETの縦断的研究　−健常高齢者、軽度認知障害、アルツハイマー病における変化―"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:10:45.056135+00:00"}