{"created":"2023-05-15T14:47:02.281303+00:00","id":64512,"links":{},"metadata":{"_buckets":{"deposit":"6d6f3b0c-5db7-4a28-89ea-5da0c98daa91"},"_deposit":{"created_by":1,"id":"64512","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64512"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064512","sets":["10:29"]},"author_link":["635921","635917","635914","635918","635924","635915","635911","635912","635916","635923","635925","635919","635920","635922","635913","635910","635926"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-10-29","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"非定型抗精神病薬は、定型抗精神病薬に比べて錐体外路症状の発現率が低く、同等の\n臨床効果を示すことが特徴とされる。その機序について、非定型抗精神病薬が辺縁系\nのD<SUB>2</SUB>受容体を選択的に遮断するという仮説が提唱されている。本研究で\nは、非定型抗精神病薬の一つであるドーパミンD2受容体部分アゴニスト抗精神病薬に\nよるD<SUB>2</SUB>受容体占有率の脳内局所差の有無を検討した。男性健常者5名を対\n象に、未服薬状態と第3世代抗精神病薬(アリピプラゾール 6mg)服薬後のPET検査を施\n行し、[C-11]racloprideおよび[C-11]FLB457による線条体および線条体外のドーパミ\nンD<SUB>2</SUB>受容体占有率を測定した。各部位の占有率は、線条体で71%±3%、線\n条体外では視床で58%±9%、前頭葉で53%±9%、側頭葉で58%±3%、頭頂葉で58%±5%で\nあり、辺縁系などの線条体外での占有率が線条体よりも高いとは言えず、また線条体\n外における占有率にも明らかな脳内局所差はみられなかった。以上より、第２世代抗\n精神病薬における辺縁系に選択的なレセプター占有を支持する結果は得られなかった","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第５１回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高畑, 圭輔"}],"nameIdentifiers":[{"nameIdentifier":"635910","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"635911","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"635912","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 泰之"}],"nameIdentifiers":[{"nameIdentifier":"635913","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原, 広臨"}],"nameIdentifiers":[{"nameIdentifier":"635914","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高, 文聰"}],"nameIdentifiers":[{"nameIdentifier":"635915","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"635916","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木, 健至"}],"nameIdentifiers":[{"nameIdentifier":"635917","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"635918","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑 圭輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635919","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635920","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635921","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原 広臨","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木 健至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635926","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ドーパミンD2受容体部分アゴニスト抗精神病薬によるドーパミンD2受容体占有率の脳内局所差に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ドーパミンD2受容体部分アゴニスト抗精神病薬によるドーパミンD2受容体占有率の脳内局所差に関する検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-02-23"},"publish_date":"2012-02-23","publish_status":"0","recid":"64512","relation_version_is_last":true,"title":["ドーパミンD2受容体部分アゴニスト抗精神病薬によるドーパミンD2受容体占有率の脳内局所差に関する検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:10:46.405969+00:00"}