{"created":"2023-05-15T14:46:59.216015+00:00","id":64460,"links":{},"metadata":{"_buckets":{"deposit":"80a9afe3-6c31-41f1-b08e-ec96f0e52a26"},"_deposit":{"created_by":1,"id":"64460","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64460"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064460","sets":["10:29"]},"author_link":["635514","635511","635509","635508","635504","635515","635499","635502","635501","635503","635506","635510","635512","635505","635513","635500","635516","635507"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-10-27","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】脳血流低下はアルツハイマー病（AD）の加速要因と考えられる。アミロイドトレーサーPIBを用いたPET撮像で、アミロイドβ（Aβ）沈着と同時に局所脳血流（rCBF）を評価できれば、ADモデルマウスに低灌流を起こさせてAβ沈着への影響を明らかにできる。ここではその基礎検討として、野生型マウスで左総頚動脈永久結紮を行い、PIB-PETによるrCBF評価を行なうことを目的とした。\n【方法】モデルはC57BL/6Jで作製した。結紮当日から6週間までPIB-PET撮像を行った。参照領域法(SRTM)での脳移行率小脳比R1をrCBFの指標とした。また、数例でMRI灌流画像撮像を行った。\n【結果】結紮後2週間程度までのPIB-PET初期画像では、結紮側大脳半球で広範囲なPIB集積低下が確認され、6週間後では大脳半球への集積の左右差は消失した。R1はMRI灌流画像からのrCBFの小脳比より左右差が小さいものの、これらの値はよく相関した。\n【結論】更に定量的観点からrCBF指標としてのR1評価を行えば、PIB-PETでrCBFの定量評価も可能なことが示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第５１回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"635499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"635500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤, 茂芳"}],"nameIdentifiers":[{"nameIdentifier":"635501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永, 正希"}],"nameIdentifiers":[{"nameIdentifier":"635502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山, 将浩"}],"nameIdentifiers":[{"nameIdentifier":"635503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡内, 隆"}],"nameIdentifiers":[{"nameIdentifier":"635504","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木, 伊知男"}],"nameIdentifiers":[{"nameIdentifier":"635505","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"635506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"635507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635509","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤 茂芳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永 正希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山 将浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡内 隆","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635516","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]PIBによる片側脳低灌流モデルマウスの局所脳血流量評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]PIBによる片側脳低灌流モデルマウスの局所脳血流量評価"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-12-08"},"publish_date":"2011-12-08","publish_status":"0","recid":"64460","relation_version_is_last":true,"title":["[11C]PIBによる片側脳低灌流モデルマウスの局所脳血流量評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:11:21.933202+00:00"}