{"created":"2023-05-15T14:46:58.424470+00:00","id":64442,"links":{},"metadata":{"_buckets":{"deposit":"5aece001-6afc-4046-ba5b-33b6bd9f21e2"},"_deposit":{"created_by":1,"id":"64442","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64442"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064442","sets":["10:29"]},"author_link":["635350","635353","635357","635355","635358","635351","635349","635360","635359","635356","635354","635352"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-11-19","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adaptive response(AR) and bystander effect are two important phenomena involved in biological responses to low doses of ionizing radiation(IR). Furthermore, there is a strong interest in better understanding the biological effects of high-LET radiation. In this study, we assessed in vitro the ability of priming low doses  (0.01-0.1 Gy) of X-rays and heavy-ion radiation to induce an AR to a subsequent challenging dose (1-4Gy) of high-LET IR(carbon-ion:20 and 40keV/mum, neon-ion : 150keV/mum) in cultured lymphoblastoid TK6, AHH-1 and NH32 cells. Pre-exposure of p53-competent cells (both with low-dose X-rays and high-LET IR) resulted in decreased mutation frequencies at Hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus and different H2AX phosphorylation kinetics, as compared to cells exposed to challenging radiation alone. This phenominon was independent of radiation-induced apoptosis or cell cycle effects. Taken together, our results suggested the existence of an AR to mutagenic effects of heavy-ion radiation in lymphoblastoid cells and the involvement of double-strand break repair mechanisms.\nEven though the cell directly hit by heavy-ion beams (even at low doses) are likely to suffer significant damage, our results constitute the first report to date indicating that low doses of high-LET radiation can nevertherless induce protective effects against subsequent high-LET irradiation. Taking inter-individual varianbility into account, these results might have interesting implications for high-LET radiation therapy and space research.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第５４回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{"nameIdentifier":"635349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"635350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"635351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAKIMOTO, AYANA"}],"nameIdentifiers":[{"nameIdentifier":"635352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eguchi-Kasai, Kiyomi"}],"nameIdentifiers":[{"nameIdentifier":"635353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"635354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635357","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿本 彩七","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635358","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠井 清美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635359","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635360","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"High-LET Heavy-Ion Radiation and Adaptive Response","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"High-LET Heavy-Ion Radiation and Adaptive Response"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-12-01"},"publish_date":"2011-12-01","publish_status":"0","recid":"64442","relation_version_is_last":true,"title":["High-LET Heavy-Ion Radiation and Adaptive Response"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:11:34.502188+00:00"}