@misc{oai:repo.qst.go.jp:00064442,
 author = {Vares, Guillaume and Bing, Wang and Tanaka, Kaoru and KAKIMOTO, AYANA and Eguchi-Kasai, Kiyomi and Nenoi, Mitsuru and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 王 冰 and 田中 薫 and 柿本 彩七 and 笠井 清美 and 根井 充},
 month = {Nov},
 note = {Adaptive response(AR) and bystander effect are two important phenomena involved in biological responses to low doses of ionizing radiation(IR). Furthermore, there is a strong interest in better understanding the biological effects of high-LET radiation. In this study, we assessed in vitro the ability of priming low doses  (0.01-0.1 Gy) of X-rays and heavy-ion radiation to induce an AR to a subsequent challenging dose (1-4Gy) of high-LET IR(carbon-ion:20 and 40keV/mum, neon-ion : 150keV/mum) in cultured lymphoblastoid TK6, AHH-1 and NH32 cells. Pre-exposure of p53-competent cells (both with low-dose X-rays and high-LET IR) resulted in decreased mutation frequencies at Hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus and different H2AX phosphorylation kinetics, as compared to cells exposed to challenging radiation alone. This phenominon was independent of radiation-induced apoptosis or cell cycle effects. Taken together, our results suggested the existence of an AR to mutagenic effects of heavy-ion radiation in lymphoblastoid cells and the involvement of double-strand break repair mechanisms.
Even though the cell directly hit by heavy-ion beams (even at low doses) are likely to suffer significant damage, our results constitute the first report to date indicating that low doses of high-LET radiation can nevertherless induce protective effects against subsequent high-LET irradiation. Taking inter-individual varianbility into account, these results might have interesting implications for high-LET radiation therapy and space research., 日本放射線影響学会第５４回大会},
 title = {High-LET Heavy-Ion Radiation and Adaptive Response},
 year = {2011}
}