{"created":"2023-05-15T14:46:57.805283+00:00","id":64428,"links":{},"metadata":{"_buckets":{"deposit":"dcbbcb9f-210c-4713-b370-791d6edcd6e1"},"_deposit":{"created_by":1,"id":"64428","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64428"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064428","sets":["10:29"]},"author_link":["635218","635231","635224","635226","635217","635222","635235","635237","635219","635241","635223","635212","635216","635227","635213","635242","635234","635240","635221","635238","635233","635215","635220","635232","635229","635225","635236","635230","635214","635228","635239"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-11-19","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アルツハイマー病（AD）は最も多い認知症タイプであり、その原因と疾患進行には未だ不明な点が多い。低線量照射による認知機能への影響は、生体の放射線被ばく研究にとって重要な関心事項である。動物を用いた最新の研究では、脳内のAD関連遺伝子の転写活性は低線量X線照射（0.1Gy）により変化した。これは照射による脳内分子ネットワーク及び分子経路への影響が、ADの進行や認知機能、そして加齢に関連している可能性があることを示している。低線量照射による認知機能やAD病理への影響を検討するために、C57BL/6Jマウスに対してX線（0.1Gy）または炭素線（0.05Gyまたは0.1Gy）で全身照射を行った後、海馬を採取し、AD関連遺伝子の発現を解析した。また、学習や記憶機能はモーリス水迷路テストを用いて評価した。アミロイドβペプチド（Aβ）の沈着はPETによるアミロイドイメージングを用いて評価した。ADの病理学的変化はアミロイド前駆タンパク（APP）、Aβ、タウ蛋白並びにリン酸化タウ蛋白の免疫染色により評価した。その結果、照射後4時間で、いくつかのAD関連遺伝子の転写レベルの顕著な変化が検出されたが、１年後、その変化は認められなかった。また、学習や記憶機能に変化はなかった。アミロイドの沈着や、APP、Aβ、タウ及びリン酸化タウの発現には、照射後の４ヶ月及び２年においても有意な変化が認められなかった。これらの結果から、低線量単回照射は、AD関連遺伝子に転写レベルの変化を誘導するが、認知機能やAD病理に有意な変化を起こすことはない事が示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第54回日本放射線影響学会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"635212","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 薫"}],"nameIdentifiers":[{"nameIdentifier":"635213","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"季, 斌"}],"nameIdentifiers":[{"nameIdentifier":"635214","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野, 麻衣子"}],"nameIdentifiers":[{"nameIdentifier":"635215","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"方, 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