{"created":"2023-05-15T14:46:56.348649+00:00","id":64395,"links":{},"metadata":{"_buckets":{"deposit":"298554df-cd6d-4734-933f-6b308df71cba"},"_deposit":{"created_by":1,"id":"64395","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64395"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064395","sets":["10:29"]},"author_link":["634873","634864","634869","634866","634872","634875","634870","634868","634876","634867","634871","634874","634865"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、がん幹細胞は腫瘍の治療抵抗性や転移能と関係するとして注目を集めている。一方、我々は、PET用低酸素検出薬剤64Cu-ATSMがマウス大腸がんColon-26腫瘍において、がん幹細胞局在領域に集積することを明らかにした（第48回JSNM）。また、64Cu-ATSM集積領域は血管が乏しいことが明らかになっており、そうした環境は低酸素かつ栄養飢餓であると考えられる。そこで我々は、64Cu-ATSMの集積とがん幹細胞の局在との関係を酸素・栄養供給の観点から検討するため、低酸素・栄養飢餓下で一定時間培養したColon-26細胞について64Cu-ATSMの取込並びにがん幹細胞比率の変動について評価した。低酸素・栄養飢餓処理後、がん幹細胞比率は上昇した。また、64Cu-ATSMの取込も、がん幹細胞比率の変動と同様に処理培養により上昇した。以上のことから、Colon-26がん幹細胞は低酸素・栄養飢餓耐性を有し、64Cu-ATSM集積領域で有利に生存している可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第49回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉井, 幸恵"}],"nameIdentifiers":[{"nameIdentifier":"634864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 佑哉"}],"nameIdentifiers":[{"nameIdentifier":"634865","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清野, 泰"}],"nameIdentifiers":[{"nameIdentifier":"634866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇, 厚生"}],"nameIdentifiers":[{"nameIdentifier":"634867","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺, 亮"}],"nameIdentifiers":[{"nameIdentifier":"634868","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"634869","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉井, 裕"}],"nameIdentifiers":[{"nameIdentifier":"634870","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 高子"}],"nameIdentifiers":[{"nameIdentifier":"634871","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"浅井, 竜哉"}],"nameIdentifiers":[{"nameIdentifier":"634872","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤林, 靖久"}],"nameIdentifiers":[{"nameIdentifier":"634873","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"634874","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉井 幸恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634875","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634876","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"64Cu-ATSMイメージング: 低酸素・栄養飢餓とがん幹細胞との関係に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"64Cu-ATSMイメージング: 低酸素・栄養飢餓とがん幹細胞との関係に関する検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-11-14"},"publish_date":"2011-11-14","publish_status":"0","recid":"64395","relation_version_is_last":true,"title":["64Cu-ATSMイメージング: 低酸素・栄養飢餓とがん幹細胞との関係に関する検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:12:06.232822+00:00"}