{"created":"2023-05-15T14:46:55.237337+00:00","id":64370,"links":{},"metadata":{"_buckets":{"deposit":"30f1c48a-a4cd-4afd-b682-3ba89cc8ebfb"},"_deposit":{"created_by":1,"id":"64370","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64370"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064370","sets":["10:29"]},"author_link":["634628","634624","634621","634626","634625","634622","634620","634623","634619","634627"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-10-29","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】PETでは薬物を直接標識することにより、ヒト生体で当該物質の動態・分布を見ることが可能である。sulpirideは長年向精神薬として汎用されているにもかかわらず、脳移行性が低いことが示唆されているが、我々は sulpirideを標識した[C-11]sulpirideを開発し、sulpirideの体内分布に関する予備的検討を行った。【方法】健常若年男性2名を対象に、PET-CTを用いて[C-11]sulpiride投与30分後から頭部から大腿部まで3分ずつ8ベッドの撮像を行った。さらに、非標識のsulpiride 500mgを経口投与3時間後に再び[C-11]sulpiride PETを施行し、分布の変化を観察した。【結果と結論】[C-11]sulpirideのベースライン時の集積は脳できわめて低く、代謝臓器である肝臓や主たる排泄経路である腎・尿路系で高かった。また、薬理量を負荷した後は2例とも[C-11]sulpirideの肝臓への集積が減少した(投与放射能に対する分布の割合で平均12.6%から5.0%)。その原因の一つとして肝臓の薬物トランスポーターの関与の可能性が考えられたが、今後さらに詳細な検討が必要である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第51回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"634619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"634620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"634621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 泰之"}],"nameIdentifiers":[{"nameIdentifier":"634622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"634623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634628","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"PETを用いた[C-11]sulpirideの全身分布と薬理量負荷後の変化の予備的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PETを用いた[C-11]sulpirideの全身分布と薬理量負荷後の変化の予備的検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-11-02"},"publish_date":"2011-11-02","publish_status":"0","recid":"64370","relation_version_is_last":true,"title":["PETを用いた[C-11]sulpirideの全身分布と薬理量負荷後の変化の予備的検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:12:23.510965+00:00"}