{"created":"2023-05-15T14:46:53.991201+00:00","id":64342,"links":{},"metadata":{"_buckets":{"deposit":"490c86f7-e881-4def-ab72-99b67078f2ec"},"_deposit":{"created_by":1,"id":"64342","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64342"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064342","sets":["10:29"]},"author_link":["634377","634378","634383","634385","634380","634384","634386","634382","634379","634381"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-10-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Poly(ADP-ribose) glycohydrolase (Parg) is the main enzyme for poly(ADP-ribose) degradation. The impact of Parg and poly(ADP-ribose) polymerase-1 (Parp-1) deficiency for sensitization of low to high linear-energy-transfer (LET) radiation was studied in mouse ES cells. Parg-/- cells showed higher sensitivity to -irradiation compared to Parp-1-/- cells. Augmented H2AX levels in Parg-/- ES cells implied a delayed repair of double strand breaks. Parg-/- ES cells show increased apoptotic ladder formation after irradiation. The effect of Parg and Parp-1 deficiency on responses to heavy ion irradiation of carbon- and Fe-ions was investigated. Parg-/- and Parp-1-/- ES cells showed enhanced apoptosis 24 hrs after carbon-ion irradiation. Parg-/- cells showed sensitization after 5 Gy carbon-ion irradiation in clonogenic survival assay, whereas clear sensitization was not noticed for Parp-1-/- ES cells. Notably, sensitization was observed at higher dose than 2 Gy for both LET 13 and 70 carbon-radiation. \nThese results suggests that Parg deficiency sensitized mouse ES cells to radiation of a wide therapeutic range of LET values with enhanced apoptotic cell death induction.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第70回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shirai, Hidenori"}],"nameIdentifiers":[{"nameIdentifier":"634377","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirai, Takahisa"}],"nameIdentifiers":[{"nameIdentifier":"634378","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasai, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"634379","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"634380","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masutani, Mitsuko"}],"nameIdentifiers":[{"nameIdentifier":"634381","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白井 秀徳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634382","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平井 崇久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笹井 啓資","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"益谷 美都子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"634386","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Parg deficiency sensitizes to radiation of low-high LET with enhanced apoptosis induction in mouse ES cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Parg deficiency sensitizes to radiation of low-high LET with enhanced apoptosis induction in mouse ES cells"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-10-06"},"publish_date":"2011-10-06","publish_status":"0","recid":"64342","relation_version_is_last":true,"title":["Parg deficiency sensitizes to radiation of low-high LET with enhanced apoptosis induction in mouse ES cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:12:42.034384+00:00"}