{"created":"2023-05-15T14:46:48.981948+00:00","id":64229,"links":{},"metadata":{"_buckets":{"deposit":"3a0ce442-7999-4883-b66d-f9302af07610"},"_deposit":{"created_by":1,"id":"64229","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64229"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064229","sets":["10:29"]},"author_link":["633421","633426","633415","633418","633422","633428","633420","633427","633424","633433","633431","633419","633432","633435","633425","633416","633429","633423","633430","633417","633434"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-04-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Carbon ion radiotherapy (CIRT) for non-small cell\nlung cancer (NSCLC) is an effective and low invasive\ntherapy with an excellent local control rate but there have\nbeen few histopathologic observations about the effect of\nCIRT on the human body. In this study, we aimed to explore\npeptides that reflect the effect of CIRT on NSCLC with\nmatrix-assisted laser desorption/ionization time-of-flight mass\nspectrometry (MALDI-TOF MS) serum profiling.\nMethods and Materials: We enrolled 36 NSCLC patients who\nunderwent CIRT in our hospital from September, 2006 to\nFebruary, 2008. Serum samples were collected from these\npatients before treatment and 1 day and 1, 3, 6 months after\ntreatment. We then prepared 5 µL of serum with magnetic\nbeads and profiled serum proteome using MALDI-TOF MS.\nResults: Nine peaks showed significant changes before and\nafter treatment. We identified the 2861 Da peak as a\nfibrinogen alpha chain fragment. The 2861 Da peptide was\nupregulated soon after irradiation and then declined\nimmediately, and this change was dependent on the dose per\nfraction. Additionally, 5890 Da and 7738 Da peak are likely to\nbe the peptides which we had identified in our former study.\nThese peaks changed gradually soon after irradiation.\nConclusions: These serum peptides were considered to reflect\nthe vital reaction and treatment effect after CIRT.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Ｈ20年度HIMAC共同利用研究成果発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中嶋, 美緒"}],"nameIdentifiers":[{"nameIdentifier":"633415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"梅村, 啓史"}],"nameIdentifiers":[{"nameIdentifier":"633416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬場, 雅行"}],"nameIdentifiers":[{"nameIdentifier":"633417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 直敬"}],"nameIdentifiers":[{"nameIdentifier":"633418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"本村, 真理"}],"nameIdentifiers":[{"nameIdentifier":"633419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 泰寿"}],"nameIdentifiers":[{"nameIdentifier":"633420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清水, 一範"}],"nameIdentifiers":[{"nameIdentifier":"633421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須金, 紀雄"}],"nameIdentifiers":[{"nameIdentifier":"633422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"朝長, 毅"}],"nameIdentifiers":[{"nameIdentifier":"633423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野村, 文夫"}],"nameIdentifiers":[{"nameIdentifier":"633424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江, 純悦"}],"nameIdentifiers":[{"nameIdentifier":"633425","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 正"}],"nameIdentifiers":[{"nameIdentifier":"633426","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中嶋 美緒","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"633427","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬場 雅行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"633428","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本 直敬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"633429","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"本村 真理","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"633430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 泰寿","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"633431","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清水 一範","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"633432","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須金 紀雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"633433","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江 純悦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"633434","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"633435","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"非小細胞肺癌の炭素イオン線治療前後におけるプロテオーム変化の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"非小細胞肺癌の炭素イオン線治療前後におけるプロテオーム変化の解析"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-02-25"},"publish_date":"2011-02-25","publish_status":"0","recid":"64229","relation_version_is_last":true,"title":["非小細胞肺癌の炭素イオン線治療前後におけるプロテオーム変化の解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:13:59.938229+00:00"}