@misc{oai:repo.qst.go.jp:00064229,
 author = {中嶋, 美緒 and 梅村, 啓史 and 馬場, 雅行 and 山本, 直敬 and 本村, 真理 and 山田, 泰寿 and 清水, 一範 and 須金, 紀雄 and 朝長, 毅 and 野村, 文夫 and 溝江, 純悦 and 鎌田, 正 and 中嶋 美緒 and 馬場 雅行 and 山本 直敬 and 本村 真理 and 山田 泰寿 and 清水 一範 and 須金 紀雄 and 溝江 純悦 and 鎌田 正},
 month = {Apr},
 note = {Purpose: Carbon ion radiotherapy (CIRT) for non-small cell
lung cancer (NSCLC) is an effective and low invasive
therapy with an excellent local control rate but there have
been few histopathologic observations about the effect of
CIRT on the human body. In this study, we aimed to explore
peptides that reflect the effect of CIRT on NSCLC with
matrix-assisted laser desorption/ionization time-of-flight mass
spectrometry (MALDI-TOF MS) serum profiling.
Methods and Materials: We enrolled 36 NSCLC patients who
underwent CIRT in our hospital from September, 2006 to
February, 2008. Serum samples were collected from these
patients before treatment and 1 day and 1, 3, 6 months after
treatment. We then prepared 5 µL of serum with magnetic
beads and profiled serum proteome using MALDI-TOF MS.
Results: Nine peaks showed significant changes before and
after treatment. We identified the 2861 Da peak as a
fibrinogen alpha chain fragment. The 2861 Da peptide was
upregulated soon after irradiation and then declined
immediately, and this change was dependent on the dose per
fraction. Additionally, 5890 Da and 7738 Da peak are likely to
be the peptides which we had identified in our former study.
These peaks changed gradually soon after irradiation.
Conclusions: These serum peptides were considered to reflect
the vital reaction and treatment effect after CIRT., Ｈ20年度HIMAC共同利用研究成果発表会},
 title = {非小細胞肺癌の炭素イオン線治療前後におけるプロテオーム変化の解析},
 year = {2009}
}