@misc{oai:repo.qst.go.jp:00064228,
 author = {須金, 紀雄 and 馬場, 雅行 and 中嶋, 美緒 and 山本, 直敬 and 宮本, 忠昭 and 鎌田, 正 and 神立, 進 and 溝江, 純悦 and 須金 紀雄 and 馬場 雅行 and 中嶋 美緒 and 山本 直敬 and 宮本 忠昭 and 鎌田 正 and 神立 進 and 溝江 純悦},
 month = {Apr},
 note = {Purpose: The conventional radiotherapy was
unsuitable for the lung cancer patient with
interstitial pneumonia (IP), but we expect that the
patients are treated with carbon ion radiotherapy
(CIRT) more safely and effectively. We evaluated
the changes of interstitial pneumonia in serologic
tests, pulmonary function tests and CT scans before
and after CIRT.
Methods: We analyzed 131 cases that performed
CIRT as the phase I/II dose escalation clinical study
(protocol: #0201) by single fractionation for stage I
non small-cell lung cancer (NSCLC), between April
2003 and December 2006. We evaluated pulmonary
function tests (vital capacity (VC), forced
expiratory volume in one second (FEV), carbon
monoxide diffusing capacity (DLCO)), serologic
tests (KL-6, SP-D, LDH) and CT scans before and
after CIRT until two years every six months.
Results and Conclusions: We revealed that DLCO
and %DLCO decreased for the patients with
interstitial changes on CT scans before CIRT. The
levels of KL-6, SP-D were increased in the cases
with interstitial changes on CT scans On CT scan,
there was the change increasing slightly
ground-glass opacities in limited local area of the
lung after CIRT. In this study, we could analyze
only 7 cases with the interstitial changes. We could
not necessarily estimate that the patients with the
interstitial pneumonia decrease pulmonary
functions significantly. We have to analyze more
patients treated by CIRT with interstitial changes., H20年度HIMAC共同利用研究成果発表会},
 title = {間質性肺炎に合併した肺癌に対する炭素イオン線治療による間質性肺炎への影響についての検討},
 year = {2009}
}