{"created":"2023-05-15T14:46:43.851830+00:00","id":64113,"links":{},"metadata":{"_buckets":{"deposit":"22691d94-f2f8-4470-837f-151bd050fc8f"},"_deposit":{"created_by":1,"id":"64113","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64113"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064113","sets":["10:29"]},"author_link":["632461","632464","632462","632466","632467","632454","632457","632451","632455","632452","632456","632458","632460","632450","632459","632453","632463","632465"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-11-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】アミロイド沈着と脳血流の低下との関係を明らかにする。【対象・方法】対象はAD12例（70±10歳、罹病期間2.8±2年）、健常者11例（65±12歳）である。方法は[11C]PIBを約360MBq静脈投与し、HR+スキャナーにて90分間撮像した。解剖学的標準化を行い、血漿入力関数を用いて2組織4パラメーターモデル（非線形最少二乗法）で解析し、ボクセル単位のK1（血流の指標）とk3(アミロイド沈着の指標)を求めた。【結果】K1は外側および内側頭頂皮質、側頭皮質においてAD群で健常群と比べて低下していた(p <0.001)。k3は、前頭連合野、側頭-頭頂連合野においてAD群において健常群と比べて高かった（p <0.0001）。外側頭頂皮質（39野）においてK1とk3の間に逆相関（p<0.01）を、楔前部（7野）においてゆるい逆相関（p<0.1）を認めた。前頭、側頭、後頭皮質では相関を認めなかった。【結論】アミロイド沈着と血流低下は頭頂皮質を除いて相関しない。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第50回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"632450","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"632451","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"632452","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 典子"}],"nameIdentifiers":[{"nameIdentifier":"632453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 康一"}],"nameIdentifiers":[{"nameIdentifier":"632454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士, 清"}],"nameIdentifiers":[{"nameIdentifier":"632455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"632456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"632457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"632458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632461","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 康一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632467","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]PIB PETにおける脳血流の低下とアミロイド沈着の相関について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]PIB PETにおける脳血流の低下とアミロイド沈着の相関について"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-11-18"},"publish_date":"2010-11-18","publish_status":"0","recid":"64113","relation_version_is_last":true,"title":["[11C]PIB PETにおける脳血流の低下とアミロイド沈着の相関について"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:15:17.313636+00:00"}