{"created":"2023-05-15T14:46:42.252847+00:00","id":64077,"links":{},"metadata":{"_buckets":{"deposit":"14976e69-da68-41a3-85d3-a05f1533b14c"},"_deposit":{"created_by":1,"id":"64077","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64077"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064077","sets":["10:29"]},"author_link":["632107","632102","632098","632101","632105","632110","632111","632114","632108","632113","632106","632099","632097","632109","632103","632104","632100","632112"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-10-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CT検査等による放射線の医学利用が急増し、低線量放射線被ばくにより発がんリスクが如何に変化するのか正確に知ることの社会的必要性が高まっている。精度の高い疫学データーに加え、放射線発がんメカニズムの理解に基づいた論理的な推定が望まれるが、メカニズムの解明には、放射線に敏感な動物発がんモデルが有用であり、放射線誘発腫瘍の特徴の同定が糸口となりうる。我々は、C3B6F1系統のPtch1ヘテロ欠損マウスに生じた髄芽腫を解析し、非照射実験群の腫瘍には認められないゲノム異常(正常Ptch1の染色体中間部欠失型不活性化)が、生後1日齢での低線量照射群(50mGyや100mGy)を含めた7実験群の腫瘍において検出されることを昨年の本大会で報告した。このゲノム異常を持つ腫瘍発生頻度は低線量域において線量に応じて直線的に増加し、50mGy程度の領域でのしきい線量不在を示唆した。\n次に、放射線誘発髄芽腫の特徴解明の目的で、この異常を放射線誘発腫瘍の指標として自然発がん型と放射線誘発型に腫瘍を分類し、死亡日齢、病理切片、遺伝子発現、CpG islandメチル化、miRNA発現等を比較した。組織学的に顕著な違いは認められなかったが、放射線誘発型腫瘍の方が全体として有意に早く死亡したマウスに生じていた。また、mRNAとmiRNA発現量の違いや、それらと一部相関したCpGアイランドメチル化レベルの違いも認められた。これらには、髄芽腫の起源である小脳顆粒前駆細胞の正常発生過程の限られた段階で重要な役割を持つ遺伝子(Plagl1やTgfb2など)の違いが含まれており、自然発がん型と放射線誘発型で発がんのタイミングが異なっている可能性が示唆された。また、他の2つの遺伝子については、発現量と死亡日齢の間に強い相関が認められた。これらの結果から放射線誘発髄芽腫の特徴とそれらから予想される発がん機構について考察する。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要(会議名, 開催地, 会期, 主催者等)","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第53回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高畠, 貴志"}],"nameIdentifiers":[{"nameIdentifier":"632097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石田, 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