{"created":"2023-05-15T14:46:41.280854+00:00","id":64056,"links":{},"metadata":{"_buckets":{"deposit":"296fc47f-1076-411a-ad5f-1000e9c674e2"},"_deposit":{"created_by":1,"id":"64056","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64056"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064056","sets":["10:29"]},"author_link":["631964","631961","631965","631958","631963","631954","631960","631955","631957","631956","631962","631959"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-05-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】大脳皮質基底核変性症(CBD)、進行性核上性麻痺(PSP)、前頭側頭型認知症(FTD)は認知機能障害と運動障害などの共通した臨床徴候を有し、病態として同じスペクトラムに位置づけられる。これらの疾患に対してPETを用いて脳内アセチルコリンエステラーゼを in vivo定量解析し、健常者との差異に関して検討した。【方法】本研究では[11C]MP4A PET をCBD7例(67.6±5.9才)、PSP12例（68.5±4.1才）、FTD8例（59.8±6.9才）患者に実施し健常者16例（61.2±8.5才)と比較した。空間的標準化と平滑化によりボクセル毎k3値（アセチルコリンエステラーゼ活性）を推定した。【結果】健常者と比較してCBDにおいては両側中心回周囲、頭頂後頭葉、前頭葉眼窩面に、PSPにおいては中心回周囲と視床においてk3値の低下を認めたがFTDでは健常者と変わらなかった。(p＜0.05, cluster corrected)【結論】コリン神経障害はCBD、PSP、FTDの間で異なる脳部位で認められ、コリン神経系関連薬剤の有効性に差があると考えられる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第51回日本神経学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"631954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"631955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"631956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"631957","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"631958","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"631959","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631960","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631961","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631965","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"大脳皮質基底核変性症、進行性核上性麻痺、前頭側頭型認知症のコリン神経画像","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大脳皮質基底核変性症、進行性核上性麻痺、前頭側頭型認知症のコリン神経画像"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-10-12"},"publish_date":"2010-10-12","publish_status":"0","recid":"64056","relation_version_is_last":true,"title":["大脳皮質基底核変性症、進行性核上性麻痺、前頭側頭型認知症のコリン神経画像"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:15:55.883087+00:00"}