{"created":"2023-05-15T14:46:40.918642+00:00","id":64048,"links":{},"metadata":{"_buckets":{"deposit":"69b981ab-162c-4f96-9d7b-914d457954bb"},"_deposit":{"created_by":1,"id":"64048","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64048"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064048","sets":["10:29"]},"author_link":["631858","631868","631855","631866","631864","631863","631862","631859","631861","631857","631856","631867","631860","631865"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-09-29","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently we have investigated that the mutation frequency at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus, which was detected with measuring 6-thioguanine resistant clones, in normal human fibroblasts induced by the 200kVp X-ray challenging dose (1.5Gy) was reduced at 0.15 times in cells pre-treated with low-dose-rate neutrons (1mSv/8h) as a priming dose compared to unpre-treated cells. Furthermore, the reduced mutation frequency was returned to the control level, when using a specific inhibitor of gap-junction mediated cell-cell communication (40µM lindane). We set up a hypothesis that recoiled protons emitted by the interaction between primary neutrons and surroundings near irradiated cells induce radio-adaptive response in irradiated cell population via gap-junction mediated bystander effect. To examine the hypothesis around 1.5% of total cells were irradiated with single 3.4MeV proton before irradiating the X-ray challenging dose using the microbeam irradiation system, Single Particle Irradiation system to Cell (SPICE) in National Institute of Radiological Sciences, Japan. The result clearly showed that the X-ray induced mutation frequency of hprt locus was suppressed in cells pre-treated with proton microbeams and returned to the control level, when using a specific inhibitor of gap-junction mediated cell-cell communication. The result suggests that neutron-induced adaptive response is caused by recoiled protons and gap-junction mediated bystander effect plays an important role to induce such cellular response.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"56th Annual Meeting of Radiation Research Society","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Masao"}],"nameIdentifiers":[{"nameIdentifier":"631855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuruoka, Chizuru"}],"nameIdentifiers":[{"nameIdentifier":"631856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konishi, Teruaki"}],"nameIdentifiers":[{"nameIdentifier":"631857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oikawa, Masakazu"}],"nameIdentifiers":[{"nameIdentifier":"631858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hua, Liu Cui"}],"nameIdentifiers":[{"nameIdentifier":"631859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaneko, Yumiko"}],"nameIdentifiers":[{"nameIdentifier":"631860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"631861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 雅雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鶴岡 千鶴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西 輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"及川 将一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631865","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"劉 翠華","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金子 由美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631867","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631868","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Radio-adaptive response of hprt mutation in normal human fibroblasts induced by proton microbeams.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radio-adaptive response of hprt mutation in normal human fibroblasts induced by proton microbeams."}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-10-04"},"publish_date":"2010-10-04","publish_status":"0","recid":"64048","relation_version_is_last":true,"title":["Radio-adaptive response of hprt mutation in normal human fibroblasts induced by proton microbeams."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:16:01.815764+00:00"}