@misc{oai:repo.qst.go.jp:00063970, author = {Bing, Wang and Tanaka, Kaoru and Vares, Guillaume and Shang, Yi and Fujita, Kazuko and Ninomiya, Yasuharu and Nakajima, Tetsuo and Eguchi-Kasai, Kiyomi and Nenoi, Mitsuru and 王 冰 and 田中 薫 and Guillaume Vares and 尚 奕 and 藤田 和子 and 二宮 康晴 and 中島 徹夫 and 笠井 清美 and 根井 充}, month = {Jul}, note = {Characterization of radiation-induced adaptive response provides important scientific information contributing to mechanism research, radiation protection and practical application. In this study, induction of adaptive response by X-rays in combination with high LET irradiations from accelerated heavy ions including carbon, neon, silicon and iron particles was attempted in utero in fetal mice and in vivo in adult mice. In the in utero study, an adaptive response was induced by combination of priming X-irradiations with challenging heavy ion irradiations from carbon or silicon but iron particles; no adaptive response was observable for the combination of priming heavy ion irradiations from carbon, silicon or iron particles with challenging X-irradiations. In the in vivo study, an adaptive response was demonstrated by combination of priming X-irradiations with challenging heavy ion irradiations from carbon or silicon but iron particles; an adaptive response was also observable in the combination of priming heavy ion irradiations from carbon (but neon or silicon) particles with challenging X-irradiations. These findings suggest that induction of adaptive response at whole body level in mice by X-rays in combination with high LET irradiations from accelerated heavy ions is possibly a radiation quality (LET or/and particle) dependent event., 38th COSPAR Scientifc Assembly}, title = {Induction of Adaptive Response by High LET Heavy Ion Irradiations in Mice}, year = {2010} }