@misc{oai:repo.qst.go.jp:00063926, author = {Yamaya, Taiga and Yoshida, Eiji and Kinouchi, Shoko and Suga, Mikio and Inadama, Naoko and Nishikido, Fumihiko and Murayama, Hideo and Tsuji, Atsushi and Inaniwa, Taku and Yoshikawa, Kyosan and 山谷 泰賀 and 吉田 英治 and 木内 尚子 and 菅 幹生 and 稲玉 直子 and 錦戸 文彦 and 村山 秀雄 and 辻 厚至 and 稲庭 拓 and 吉川 京燦}, month = {Jun}, note = {The OpenPET geometry, which visualizes a physically opened space between two detector rings, is our new idea to enable PET imaging during radiation therapy. In particular, OpenPET is expected to realize in-beam 3D PET, which is a method for an in situ monitoring of charged particle therapy, by letting the beams pass through the gap. Chasing a moving target such as a tumor in the lung will also become possible if the real-time image reconstruction becomes available. In addition, real-time monitoring of therapeutic gain might be possible in the future when a new PET tracer that quickly responds to radiotherapy is developed. In this paper, we designed and developed the first prototype of the OpenPET for a proof-of-concept. The prototype system was designed mainly for three purposes: (1) to provide an initial demonstration of the OpenPET concept; (2) to acquire basic parameters to design human-size in-beam OpenPET; and (3) to carry out an experimental study of tumor response to radiotherapy in small animals., SNM 2010 Annual Meeting}, title = {Development of a small animal OpenPET prototype for a proof-of-concept of PET imaging during radiation therapy}, year = {2010} }