{"created":"2023-05-15T14:46:33.554466+00:00","id":63884,"links":{},"metadata":{"_buckets":{"deposit":"0579873b-cc12-4a54-8709-8475f062db80"},"_deposit":{"created_by":1,"id":"63884","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63884"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063884","sets":["10:29"]},"author_link":["630289","630291","630290","630294","630295","630286","630293","630287","630299","630297","630296","630301","630302","630285","630300","630288","630298","630292"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-04-20","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】炭素イオン線照射と免疫療法（樹状細胞療法）の併用療法について、その遠隔転移制御効果について評価する。\n【材料と方法】マウス扁平上皮癌細胞 NR-S1を下肢に移植したC3H/HeMsNrs マウス下肢に炭素線6Gy (290 MeV/nucleon, 6 cm SDBP) を照射し、照射後、36時間後、α-galactosylceramide (α-GalCer)-pulsed dendritic cells を局所腫瘍に注射した。遠隔転移制御効果を免疫組織学的に解析した。\n【結果】局所腫瘍の大きさは、コントロール、炭素線単独照射群、併用療法群で差は認められなかった。一方、肺転は、炭素イオン線＋樹状細胞併用療法によって有意に抑制された。免疫組織学的解析により、炭素イオン線照射により、局所腫瘍細胞において免疫応答に関与する因子ICAM-1の発現が増加し、さらに、炭素イオン線照射単独と比較して、炭素イオン線＋樹状細胞併用群では、肺組織において、pre-metastatic phase で重要な機能を有するS100A8発現が抑制された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"HIMAC共同利用研究 成果発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤田, 英俊"}],"nameIdentifiers":[{"nameIdentifier":"630285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川, 眞由美"}],"nameIdentifiers":[{"nameIdentifier":"630286","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保, 悠"}],"nameIdentifiers":[{"nameIdentifier":"630287","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村, 悦子"}],"nameIdentifiers":[{"nameIdentifier":"630288","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中渡, 美也子"}],"nameIdentifiers":[{"nameIdentifier":"630289","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今留, 香織"}],"nameIdentifiers":[{"nameIdentifier":"630290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, いづみ"}],"nameIdentifiers":[{"nameIdentifier":"630291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田, 知子"}],"nameIdentifiers":[{"nameIdentifier":"630292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井, 高志"}],"nameIdentifiers":[{"nameIdentifier":"630293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 英俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 悠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 悦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中渡 美也子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630298","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今留 香織","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630299","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 いづみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630300","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 知子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630301","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630302","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"マウスモデルを用いた炭素イオン線治療併用療法研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウスモデルを用いた炭素イオン線治療併用療法研究"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-05-13"},"publish_date":"2010-05-13","publish_status":"0","recid":"63884","relation_version_is_last":true,"title":["マウスモデルを用いた炭素イオン線治療併用療法研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:17:54.813209+00:00"}