{"created":"2023-05-15T14:46:33.239760+00:00","id":63877,"links":{},"metadata":{"_buckets":{"deposit":"40f6a424-5613-4ea7-b045-e6c3128e3b6b"},"_deposit":{"created_by":1,"id":"63877","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63877"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063877","sets":["10:29"]},"author_link":["630240","630237","630242","630243","630239","630246","630245","630241","630236","630247","630238","630244","630235","630234","630248"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-11-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】近年、発達期における放射線の影響について注目されているが、詳細な報告は少ない。そこで我々は、発達期および成体期における放射線被ばく時年齢依存性について、生体組織の中でも特に放射線感受性の高い腸管のアポトーシスを指標に比較し、発達期における放射線の急性影響について検討した。\n【材料と方法】発達期および成体期の腸管を比較検討するため、初めに胎児期18日齢〜生後7週齢の腸管をHE染色で形態学的に観察し、各発達段階における特徴を把握した。次に、授乳期（2週齢）および成体期（7週齢）でX線2Gyを全身照射し、照射後3時間、6時間、12時間、24時間における小腸ならびに大腸のアポトーシスをactive caspase3抗体染色により判定した。各群ともに雌雄3匹ずつ用い、apoptic index（half crypt当たりのアポトーシス細胞数）を測定した。\n【結果】形態学的観察の結果、胎児期や生後直後には認められなかったcrypt構造が、授乳期である2週齢では小さいサイズながらも認められ、成体期である7週齢では成熟した構造として観察された。次に2週齢と7週齢における放射線誘発アポトーシスを比較した予備的な実験では、アポトーシス細胞数がピークに達するまでの時間に差がみられた。現在我々は個体数を増やして解析を進めており、さらに詳細な結果を報告する。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第52回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今村, 智子"}],"nameIdentifiers":[{"nameIdentifier":"630234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼, 志津子"}],"nameIdentifiers":[{"nameIdentifier":"630235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上西, 睦美"}],"nameIdentifiers":[{"nameIdentifier":"630236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村, 由希子"}],"nameIdentifiers":[{"nameIdentifier":"630237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古渡, 礼恵"}],"nameIdentifiers":[{"nameIdentifier":"630238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡本, 美恵子"}],"nameIdentifiers":[{"nameIdentifier":"630239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"室伏, きみ子"}],"nameIdentifiers":[{"nameIdentifier":"630240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 義也"}],"nameIdentifiers":[{"nameIdentifier":"630241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今村 智子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上西 睦美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 由希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630245","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古渡 礼恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630246","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡本 美恵子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630247","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"630248","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"マウス腸管における放射線誘発アポトーシスの被ばく時年齢依存性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス腸管における放射線誘発アポトーシスの被ばく時年齢依存性"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-04-27"},"publish_date":"2010-04-27","publish_status":"0","recid":"63877","relation_version_is_last":true,"title":["マウス腸管における放射線誘発アポトーシスの被ばく時年齢依存性"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:17:59.424347+00:00"}