{"created":"2023-05-15T14:46:31.460693+00:00","id":63841,"links":{},"metadata":{"_buckets":{"deposit":"65565f38-8d8f-47c9-b54c-b53969ab8556"},"_deposit":{"created_by":1,"id":"63841","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63841"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063841","sets":["10:29"]},"author_link":["629820","629828","629827","629829","629825","629822","629824","629830","629819","629818","629821","629826","629817","629823","629816"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-05-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】無症候FTDP-17変異遺伝子保因者(PGC)において脳内のミクログリアの活性化が早期からみられるか否かを検討する。【対象・方法】N279K変異を持つ白人3名(PGC1-3: 38歳から41歳)とその兄弟1名（PGC 4、遺伝子未検、37歳）が画像検査のために来日した。英文で書かれた説明書を用いて同意を得た。方法はMRIと [11C]DAA1106、L-[β-11C]DOPA、[11C]MP4Aを放射性薬剤として用いたPETを3日間のうちに行い、それぞれの検査において健常被験者と比較した。【結果・結論】PGC1-4は神経学的検査、心理検査において異常なかった。PGC1, 2ではMRIにて海馬の萎縮がみられた。PGC1-4ではミクログリアの活性化はみられなかった。PGC1-3において線条体のL-[β-11C]DOPAの取り込みが低下していた。PGC1-4においてコリン神経系機能の低下はみられなかった。 PGCにおいて海馬は萎縮する例があり、黒質線条体ドパミン系機能低下もみられるが、活性化ミクログリアはPETでは検出されない。PGCの発症時期予測にはMRI、PETによる黒質線条体ドパミン機能の測定が有用である可能性が示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第50回日本神経学会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"629816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三好, 美智恵"}],"nameIdentifiers":[{"nameIdentifier":"629817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"629818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士, 清"}],"nameIdentifiers":[{"nameIdentifier":"629819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"629820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"629821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"629822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"629823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三好 美智恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629830","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"無症候FTDP-17変異遺伝子保因者におけるPET, MRIの検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"無症候FTDP-17変異遺伝子保因者におけるPET, MRIの検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-15"},"publish_date":"2010-03-15","publish_status":"0","recid":"63841","relation_version_is_last":true,"title":["無症候FTDP-17変異遺伝子保因者におけるPET, MRIの検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:18:23.920071+00:00"}