{"created":"2023-05-15T14:46:31.144867+00:00","id":63834,"links":{},"metadata":{"_buckets":{"deposit":"a76b4cef-e7fe-4954-8022-c2dc6e4ae8ac"},"_deposit":{"created_by":1,"id":"63834","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63834"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063834","sets":["10:29"]},"author_link":["629720","629711","629718","629713","629712","629715","629717","629719","629723","629722","629721","629710","629714","629716"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】[11C]MNPAはドーパミンD2受容体の高親和性部位に結合するアゴニストリガンドである。このリガンドを用いて、部分アゴニスト作用を有する抗精神病薬であるアリピプラゾールのドーパミンD2受容体阻害作用を検討した。\n【方法】男性健常者10名を対象に、アリピプラゾール（0.5-12mg）服薬前後で[11C]MNPAを用いたPET検査を行い、ドーパミンD2受容体占有率を測定した。また、低親和性部位にも結合するアンタゴニストリガンドである[11C]racloprideを用いた占有率も測定し、両者を比較した。\n【結果】[11C]MNPAでのドーパミンD2受容体占有率は0-60%であり、[11C]racloprideでの占有率は4-81％であった。両リガンドでの占有率に有意な差は認められなかった。\n【考察】部分アゴニストであるアリピプラゾールは、ドーパミンD2受容体の親和性の差によらず均一なドーパミンD2受容体阻害作用を呈することが示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第49回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"荒川, 亮介"}],"nameIdentifiers":[{"nameIdentifier":"629710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"629711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高, 文聰"}],"nameIdentifiers":[{"nameIdentifier":"629712","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根, 瑞保"}],"nameIdentifiers":[{"nameIdentifier":"629713","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋, 英彦"}],"nameIdentifiers":[{"nameIdentifier":"629714","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"629715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"629716","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川 亮介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629717","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根 瑞保","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 英彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629723","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ドーパミンD2受容体アゴニストリガンド[11C]MNPAを用いたアリピプラゾールの受容体占有率測定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ドーパミンD2受容体アゴニストリガンド[11C]MNPAを用いたアリピプラゾールの受容体占有率測定"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-12"},"publish_date":"2010-03-12","publish_status":"0","recid":"63834","relation_version_is_last":true,"title":["ドーパミンD2受容体アゴニストリガンド[11C]MNPAを用いたアリピプラゾールの受容体占有率測定"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:18:28.834929+00:00"}