{"created":"2023-05-15T14:46:31.099556+00:00","id":63833,"links":{},"metadata":{"_buckets":{"deposit":"90e662e7-7362-4660-9eb7-0d209009ff39"},"_deposit":{"created_by":1,"id":"63833","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63833"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063833","sets":["10:29"]},"author_link":["629692","629698","629693","629708","629703","629705","629709","629691","629706","629701","629689","629688","629690","629695","629707","629699","629696","629704","629697","629700","629694","629702"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景】認知症に対するアセチルコリンエステラーゼ阻害薬の導入以来、神経変性疾患におけるコリン神経系障害は注目されている。大脳皮質基底核変性症(CBD)、進行性核上性麻痺(PSP)、前頭側頭型認知症(FTD)は認知機能障害と運動障害などの共通した臨床徴候を有し、病態として同じスペクトラムに位置づけられる。【対象と方法】本研究では[<SUP>11</SUP>C]MP4A PETをCBD7例(67.6±5.9才)、PSP12例（68.5±4.1才）、FTD8例（59.8±6.9才）患者に実施し健常者17例（62.8±10.6才)と比較した。空間的標準化と平滑化によりボクセル毎にK <SUB>1</SUB>値とk <SUB>3</SUB>値（アセチルコリンエステラーゼ活性）を推定した。【結果】健常者と比較してCBDにおいては両側大脳皮質に、PSPにおいては両側前頭葉、中心回周囲と視床においてk <SUB>3</SUB>値の低下を認めたがFTDでは健常者と変わらなかった。(p＜0.05, cluster corrected)【結論】コリン神経障害はCBD、PSP、FTDの間で異なる脳部位で認められる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第49回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"629688","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"629689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"629690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青墳, 章代"}],"nameIdentifiers":[{"nameIdentifier":"629691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 典子"}],"nameIdentifiers":[{"nameIdentifier":"629692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黄田, 常嘉"}],"nameIdentifiers":[{"nameIdentifier":"629693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 康一"}],"nameIdentifiers":[{"nameIdentifier":"629694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"629695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"629696","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士, 清"}],"nameIdentifiers":[{"nameIdentifier":"629697","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"629698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629699","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629700","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629701","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青墳 章代","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629703","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黄田 常嘉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 康一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629707","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629709","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"大脳皮質基底核変性症、進行性核上性麻痺、前頭側頭型認知症における脳内コリン神経パラメトリック画像","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大脳皮質基底核変性症、進行性核上性麻痺、前頭側頭型認知症における脳内コリン神経パラメトリック画像"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-12"},"publish_date":"2010-03-12","publish_status":"0","recid":"63833","relation_version_is_last":true,"title":["大脳皮質基底核変性症、進行性核上性麻痺、前頭側頭型認知症における脳内コリン神経パラメトリック画像"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:18:29.524637+00:00"}