{"created":"2023-05-15T14:46:30.826834+00:00","id":63827,"links":{},"metadata":{"_buckets":{"deposit":"8fa94369-7b16-420c-96f6-8664bccb50ee"},"_deposit":{"created_by":1,"id":"63827","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63827"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063827","sets":["10:29"]},"author_link":["629641","629650","629639","629648","629652","629654","629647","629651","629644","629653","629646","629645","629643","629640","629649","629642"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-03-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"フェリチンは主要な細胞内鉄貯蔵タンパク質として、鉄代謝の制御を通じ生体内恒常性維持に重要な役割をしている。近年、鉄貯蔵以外の機能も明らかにされてきており、その多様な機能から生化学、がん生物学、分子イメージングにわたる広い分野で興味深い分子といえる。\nフェリチンはMRIのレポーター遺伝子として注目されている。我々は、がん遺伝子治療における治療遺伝子発現のモニターとしてフェリチンが使えるのではないかと考え、フェリチンレポーターによる遺伝子発現MRイメージング法開発に取り組んだ。この目的のため、フェリチンレポーター遺伝子と赤色蛍光遺伝子を連結したプラスミドDNAを構築した。そのプラスミドDNAを、ヌードマウスに移植したヒト腫瘍に電気穿孔法（エレクトロポレーション）で導入したところ、フェリチンレポーターの遺伝子発現をT2強調画像でイメージングすることに成功した。これにより、フェリチンレポーター遺伝子が、がん遺伝子治療時の治療遺伝子発現のモニターになりうることが実証された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第一回放医研 MRI セミナープログラム","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長谷川, 純崇"}],"nameIdentifiers":[{"nameIdentifier":"629639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｕ, Ｗｉｎｎ Ａｕｎｇ"}],"nameIdentifiers":[{"nameIdentifier":"629640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"越川, 道子"}],"nameIdentifiers":[{"nameIdentifier":"629641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小畠, 隆行"}],"nameIdentifiers":[{"nameIdentifier":"629642","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池平, 博夫"}],"nameIdentifiers":[{"nameIdentifier":"629643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 高子"}],"nameIdentifiers":[{"nameIdentifier":"629644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木, 伊知男"}],"nameIdentifiers":[{"nameIdentifier":"629645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"629646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 純崇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｕ Ｗｉｎｎ Ａｕｎｇ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629648","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"越川 道子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629649","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小畠 隆行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629650","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池平 博夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"629654","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"フェリチンと生体内遺伝子発現MRイメージング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"フェリチンと生体内遺伝子発現MRイメージング"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-05"},"publish_date":"2010-03-05","publish_status":"0","recid":"63827","relation_version_is_last":true,"title":["フェリチンと生体内遺伝子発現MRイメージング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:18:33.429122+00:00"}