{"created":"2023-05-15T14:46:25.294516+00:00","id":63704,"links":{},"metadata":{"_buckets":{"deposit":"db1c0e83-4445-49f1-8772-416a124db386"},"_deposit":{"created_by":1,"id":"63704","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63704"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063704","sets":["10:29"]},"author_link":["628792","628794","628790","628789","628788","628793","628791","628787"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-11-14","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"c-kitは消化管間質腫瘍(GIST)など多く癌で高発現している。c-kit阻害剤はGISTの治療に使われており、他のc-kit高発現癌への応用も期待される。適応症例選択のために、c-kit発現腫瘍の画像診断法の開発が必要である。そこで、抗c-kit抗体のイメージングプローブとしての評価を行った。125Iと111Inで標識した抗c-kit IgGは、GIST型c-kit過剰発現ヒト細胞とc-kit高発現ヒト小細胞肺癌細胞に対して高親和性を示した。c-kitに結合後に細胞内に取り込まれることから、金属核種標識が画像化に適していることが示唆された。111In標識IgGは腫瘍へ高集積し、その画像化に成功した。IgGは血中排出が遅いため、Fabで同様に評価を行い、投与後6時間で64Cu標識Fabによる画像化に成功した。これらの結果より、c-kit高発現腫瘍の画像診断への応用の可能性が示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第9回放射性医薬品・画像診断薬研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"曽川, 千鶴"}],"nameIdentifiers":[{"nameIdentifier":"628787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 千里"}],"nameIdentifiers":[{"nameIdentifier":"628788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"628789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"628790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"曽川 千鶴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 千里","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628794","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"c-kit特異的イメージングプローブの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"c-kit特異的イメージングプローブの開発"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-11-17"},"publish_date":"2009-11-17","publish_status":"0","recid":"63704","relation_version_is_last":true,"title":["c-kit特異的イメージングプローブの開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:19:55.462909+00:00"}