{"created":"2023-05-15T14:46:25.069640+00:00","id":63699,"links":{},"metadata":{"_buckets":{"deposit":"0ac938b9-5692-45c7-8382-a39b1b27198a"},"_deposit":{"created_by":1,"id":"63699","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63699"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063699","sets":["10:29"]},"author_link":["628754","628751","628757","628752","628756","628755","628753","628749","628750"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-11-14","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"EGFRの異常発現は細胞のがん化や腫瘍の悪性化に深く関与している。我々はEGFRの活性を画像化したいと考え、アダプター分子であるGrb2のSH2ドメイン（活性化EGFRの特定のリン酸化チロシン残基と結合する領域）を基本骨格としたプローブ（TSF）を作製し、有用性について基礎的検討を行った。EGFRの発現量や活性化の違いによる標的との結合や細胞内局在、細胞内安定性を比較した結果、TSFは細胞内でEGFRと共局在し、EGFRの活性化に伴い両者の結合が増加した。またTSFはEGFR過剰発現細胞や活性化EGFRが多い細胞内でより安定に存在することがわかった。さらに125I標識したTSFを担がんマウスに尾静脈注入し体内分布を調べると、EGFR過剰発現腫瘍では投与後30分から1時間にかけて放射活性が増加した一方、低発現腫瘍や他組織では経時的に低下した。胃への顕著な集積から生体内での125Iの速やかな離脱が推測され、放射性標識法には改善が必要と考えられるが、Grb2のSH2ドメインの利用によりEGFRの活性化を画像化できる可能性が示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第9回放射性医薬品・画像診断薬研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"齋藤, 有里子"}],"nameIdentifiers":[{"nameIdentifier":"628749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 高子"}],"nameIdentifiers":[{"nameIdentifier":"628750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒野, 泰"}],"nameIdentifiers":[{"nameIdentifier":"628751","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤林, 靖久"}],"nameIdentifiers":[{"nameIdentifier":"628752","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀, 恒夫"}],"nameIdentifiers":[{"nameIdentifier":"628753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤 有里子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒野 泰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628757","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"アダプター分子を利用したEGFR標的イメージング剤の有用性検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アダプター分子を利用したEGFR標的イメージング剤の有用性検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-11-17"},"publish_date":"2009-11-17","publish_status":"0","recid":"63699","relation_version_is_last":true,"title":["アダプター分子を利用したEGFR標的イメージング剤の有用性検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:19:58.733427+00:00"}