{"created":"2023-05-15T14:46:21.449582+00:00","id":63628,"links":{},"metadata":{"_buckets":{"deposit":"90adb062-9bc7-42c5-8c11-895677ba4b52"},"_deposit":{"created_by":1,"id":"63628","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63628"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063628","sets":["10:29"]},"author_link":["627989","628000","628002","627988","628001","628005","627993","628003","628006","627997","627991","627990","627996","627994","627998","627999","627985","627986","627987","627995","628004","627992"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"GF120918及びXR9576は選択的なP糖たんぱく質（P-gp）阻害剤であり、特にGF120918は乳がん耐性たんぱく質（BCRP）にも高い阻害価を示す。我々は、脳移行性評価のための有用なPET用プローブとして[11C]GF120918と[11C]XR9576を開発してきた。本研究では、3種のKOマウス（P-gp, Bcrp, P-gp&Bcrp）と野生型マウスを用い脳PET測定により動態を比較した。[11C]GF120918では、P-gp&Bcrp KOマウスの脳の放射能濃度が野生型マウスより9倍程度上昇し、P-gp KOマウスでも3倍程度上昇した。しかしBcrp KOマウスでは違いがみられなかった。[11C]XR9576では上昇の程度は低いもののほぼ同様の結果が得られた。[11C]GF120918は脳移行性制限をより顕著に表すことが出来る優れたPET用プローブであり、薬剤の脳移行性制限を評価するPET用薬剤として期待される。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第49回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"627985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"627986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"昆野, 富士子"}],"nameIdentifiers":[{"nameIdentifier":"627987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井, 譲二"}],"nameIdentifiers":[{"nameIdentifier":"627988","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"627989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柳本, 和彦"}],"nameIdentifiers":[{"nameIdentifier":"627990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"627991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井, 誠"}],"nameIdentifiers":[{"nameIdentifier":"627992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村, 行雄"}],"nameIdentifiers":[{"nameIdentifier":"627993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村, 利光"}],"nameIdentifiers":[{"nameIdentifier":"627994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"627995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"昆野 富士子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柳本 和彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 行雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"628006","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"PET用プローブとしての2つのP-gp阻害剤（GF120918、XR9576）の脳移行性評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PET用プローブとしての2つのP-gp阻害剤（GF120918、XR9576）の脳移行性評価"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-07"},"publish_date":"2009-10-07","publish_status":"0","recid":"63628","relation_version_is_last":true,"title":["PET用プローブとしての2つのP-gp阻害剤（GF120918、XR9576）の脳移行性評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:20:48.942081+00:00"}