{"created":"2023-05-15T14:46:21.383881+00:00","id":63627,"links":{},"metadata":{"_buckets":{"deposit":"23ce58b6-6334-4be5-8e0c-d3118019def7"},"_deposit":{"created_by":1,"id":"63627","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63627"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063627","sets":["10:29"]},"author_link":["627967","627966","627970","627975","627973","627972","627979","627981","627983","627969","627976","627980","627978","627982","627968","627974","627977","627984","627971"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】無症候FTDP-17変異遺伝子保因者(PGC)において脳内病変がみられるか否かを\n検討する。【対象・方法】N279K変異を持つ白人3名(PGC1-3: 38歳から41歳)とその兄\n弟1名（PGC 4、遺伝子未検、37歳）が画像検査のために来日した。方法はMRIと [<SU\nP>11</SUP>C]DAA1106、L-[β-<SUP>11</SUP>C]DOPA、[<SUP>11</SUP>C]MP4Aを放射性\n薬剤として用いたPETを3日間のうちに行い、それぞれの検査において健常被験者と比\n較した。【結果】PGC1-4は神経学的検査、心理検査において異常なかった。PGC1, 2\nではMRIにて海馬の萎縮がみられた。PGC2では前頭葉内側、PCG1と3では後頭皮質に健\n常と比べて2標準偏差以上のDAA結合の増加（ミクログリアの活性化）がみられた。PG\nC1-3において線条体のL-[β-<SUP>11</SUP>C]DOPAの取り込み（ドパミン代謝）が低\n下していた。PGC1-4において[<SUP>11</SUP>C]MP4A PETでのk3（アセチルコリンエス\nテラーぜ活性）の低下はみられなかった。【結論】PGCの発症時期予測にはMRI、PET\nによる黒質線条体ドパミン機能の測定が有用であり、ミクログリアの活性化も一部の\n症例でみられる可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第49回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"627966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三好, 美智恵"}],"nameIdentifiers":[{"nameIdentifier":"627967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"627968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川, 亮介"}],"nameIdentifiers":[{"nameIdentifier":"627969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"627970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士, 清"}],"nameIdentifiers":[{"nameIdentifier":"627971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"627972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"627973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"627974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"627975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三好 美智恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川 亮介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627981","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627984","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"無症候FTDP-17(MAPT)変異遺伝子保因者における脳内病変　-PETとMRIによる測定-","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"無症候FTDP-17(MAPT)変異遺伝子保因者における脳内病変　-PETとMRIによる測定-"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-07"},"publish_date":"2009-10-07","publish_status":"0","recid":"63627","relation_version_is_last":true,"title":["無症候FTDP-17(MAPT)変異遺伝子保因者における脳内病変　-PETとMRIによる測定-"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:20:49.616579+00:00"}