{"created":"2023-05-15T14:46:21.250207+00:00","id":63625,"links":{},"metadata":{"_buckets":{"deposit":"8fad600a-5166-4f3f-92c5-1ef77edc9330"},"_deposit":{"created_by":1,"id":"63625","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63625"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063625","sets":["10:29"]},"author_link":["627956","627953","627957","627952","627949","627955","627954","627948","627951","627950"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[18F]フルオロミソニダゾール([18F]FMISO )は、低酸素癌細胞イメージング薬剤として用いられている。そこで、[18F]FMISO の臨床使用を目的とした製造法と品質検査法を検討した。合成法は、脱離基として、Ts基、保護基としてTHP基を有するNITTPを用いて製造した。製造の際、酸(加水分解)、熱(調剤処理)、放射線による[18F]MISO の分解が確認された。これらに対して、(1)80℃、1分の短時間で加水分解を行うことにより、酸による分解を抑制した。(2)調剤処理時のヒーターの温度の調節により、熱による分解を抑制した。(3)アスコルビン酸の添加により放射線分解が抑制され、3時間以上安定であった。また、逆相HPLCでは除去困難である脱離基のp-トルエンスルホン酸を、陰イオン交換カートリッジに通じることにより、最終製剤への混入を低下させた。今回の検討により、高収率、高品質[18F]FMISO を得ることができた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要(会議名, 開催地, 会期, 主催者等)","attribute_value_mlt":[{"subitem_description":"第49回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"林, 和孝"}],"nameIdentifiers":[{"nameIdentifier":"627948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中尾, 隆士"}],"nameIdentifiers":[{"nameIdentifier":"627949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 勇一郎"}],"nameIdentifiers":[{"nameIdentifier":"627950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤, 正敏"}],"nameIdentifiers":[{"nameIdentifier":"627951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 和年"}],"nameIdentifiers":[{"nameIdentifier":"627952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"林 和孝","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中尾 隆士","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 勇一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤 正敏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627957","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"臨床使用のための[18F]FMISOの製造法と品質検査法の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"臨床使用のための[18F]FMISOの製造法と品質検査法の検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-07"},"publish_date":"2009-10-07","publish_status":"0","recid":"63625","relation_version_is_last":true,"title":["臨床使用のための[18F]FMISOの製造法と品質検査法の検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:20:50.943442+00:00"}