{"created":"2023-05-15T14:46:21.048204+00:00","id":63622,"links":{},"metadata":{"_buckets":{"deposit":"9759f5a8-0f5e-4d65-b62c-2e5619ea953b"},"_deposit":{"created_by":1,"id":"63622","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63622"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063622","sets":["10:29"]},"author_link":["627916","627917"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】11C-PIBは最も普及したアミロイドβ(Aβ)リガンドだが脳内結合部位にはまだ不明な点が多い。そこで、詳細な動態を調べるために、Aβ蓄積をきたすモデルマウスを用いた定量を試みた。\n【方法】トランスジェニック(Tg)マウス(APP23, 23-6mo,n=4)、高齢(24mo, n=1)・若年(9-10wk, n=6)野生型(WT)マウスに11C-PIBを投与後90分間PET計測・採血を行い関心領域(ROI)の時間放射能曲線と入力関数を得た。compartment model、Logan解析でROIの分布容積VTを求め、更にVTの小脳比DVRも求めた。DVRは参照領域法(SRTM)でも求めた。\n【結果】11C-PIBの動態は若年WTでは1-tissue modelが、Tgと高齢WTでは2-tissue modelがfitした。VTは全ROIで若年WTより高齢WTやTgの方が高くなった。Tgの皮質や海馬ではAβ蓄積を反映してWTよりも高いVTとなり、SRTMによるDVRはVTの比とよく相関した(r2=0.9)。\n【結論】Tgマウスで11C-PIBの定量評価を行うことにより、領域に関らず加齢で11C-PIBの保持が高まるものの領域差はAβ集積に相関し、SRTMによってDVRが評価可能なことが裏付けられた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第49回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"627916","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627917","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"アミロイド前駆体蛋白遺伝子導入マウスにおける11C-PIB脳内結合の定量","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アミロイド前駆体蛋白遺伝子導入マウスにおける11C-PIB脳内結合の定量"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-06"},"publish_date":"2009-10-06","publish_status":"0","recid":"63622","relation_version_is_last":true,"title":["アミロイド前駆体蛋白遺伝子導入マウスにおける11C-PIB脳内結合の定量"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:20:53.032415+00:00"}