{"created":"2023-05-15T14:46:08.890270+00:00","id":63037,"links":{},"metadata":{"_buckets":{"deposit":"a1959169-b436-45b0-a908-488496bcc2b2"},"_deposit":{"created_by":1,"id":"63037","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63037"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063037","sets":["10:29"]},"author_link":["622651","622655","622662","622661","622663","622658","622653","622652","622656","622665","622664","622657","622659","622654","622660"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-03-18","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"深部癌に対する新しい化学放射線治療として、放射線感受性をもつ薬剤を腫瘍部に送達させ、体外から患部へピンポイントでX線を照射するX線Drug Delivery System (DDS) が提案されている。放射線感受性を持つ薬剤としては、重金属である金や白金を含有する薬剤が候補として挙がっている。中でもシスプラチンはDNAに結合しその機能を妨げることで抗癌作用を示す白金製剤であり、X線DDSへの応用が期待される。近年開発されたシスプラチンミセル(ナノキャリア株式会社製)は、シスプラチンを高分子ポリマーで内包したDDS薬剤であり、シスプラチン単体よりも血中滞留性が高く、腫瘍に集積しやすいという特徴がある1)。腫瘍部においてシスプラチンは高分子ポリマーから徐々に放出され、腫瘍細胞に取り込まれると考えられている。治療効果の最大化を定量的に議論するためには、実際にどの程度の薬剤が時間とともに細胞内部に取り込まれるのかを評価する必要があり、これまでにParticle Induced X-ray Emission (PIXE)分析法を用いて、細胞内白金含有量測定を行ってきた2)。しかし多数の細胞を測定する方法では、細胞内の薬剤動態を知ることはできない。そこで本研究では、マイクロビームスキャニングPIXE (micro-PIXE)を用い、個々の細胞内における白金の分布画像を得た。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第２回共用施設(PASTA&SPICE)共同研究成果報告会(第３回静電加速器利用ワークショップ)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"水野, 和恵"}],"nameIdentifiers":[{"nameIdentifier":"622651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遊佐, 訓孝"}],"nameIdentifiers":[{"nameIdentifier":"622652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西, 輝昭"}],"nameIdentifiers":[{"nameIdentifier":"622653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"及川, 将一"}],"nameIdentifiers":[{"nameIdentifier":"622654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川, 剛弘"}],"nameIdentifiers":[{"nameIdentifier":"622655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"磯, 浩之"}],"nameIdentifiers":[{"nameIdentifier":"622656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 有一"}],"nameIdentifiers":[{"nameIdentifier":"622657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今関, 等"}],"nameIdentifiers":[{"nameIdentifier":"622658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上坂, 充"}],"nameIdentifiers":[{"nameIdentifier":"622659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西 輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"622660","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"及川 将一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"622661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 剛弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"622662","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"磯 浩之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"622663","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 有一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"622664","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今関 等","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"622665","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"PIXE分析法による重金属含有X線感受型DDS化抗がん剤の細胞内分布解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PIXE分析法による重金属含有X線感受型DDS化抗がん剤の細胞内分布解析"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-03"},"publish_date":"2009-04-03","publish_status":"0","recid":"63037","relation_version_is_last":true,"title":["PIXE分析法による重金属含有X線感受型DDS化抗がん剤の細胞内分布解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:23:55.030605+00:00"}