{"created":"2023-05-15T14:46:04.846940+00:00","id":62947,"links":{},"metadata":{"_buckets":{"deposit":"78df21d0-f3d8-4392-b8d0-56ee1c0af16d"},"_deposit":{"created_by":1,"id":"62947","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62947"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062947","sets":["10:29"]},"author_link":["621846","621839","621840","621841","621837","621838","621842","621843","621836","621844","621845","621847","621848","621849","621835","621850","621834"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-18","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】\n高LETの炭素イオン線照射によるアポトーシス誘発に関与する遺伝子発現とヒト由来の固形腫瘍においてX線と比較して明らかにする.\n\\n【対象】\np53野生型の上衣芽腫, 原始神経外胚葉性腫瘍, p53変異型のヒト膠芽腫をヌードマウスに移植して, X線または炭素イオン線2Gyの1回照射をおこない, 4, 6, 24時間後にRNAを抽出してcDNAアレイ解析, 階層型クラスタリング, Gene Ontology解析, Pathway解析を実施した. 組織片\n\\n【結果】\n平均年齢は62歳(範囲:26-104歳)で, 病期別の内訳は, I期19名, II期33名, III期26名, IVa期は9名であった. 高線量率組織内照射が施行された10名中9名は局所進行例であった. 全症例の5年生存率は76%で, RTOG/EORTC分類によるグレードIII以上の遅発性有害反応は認められなかった.\n\\n【まとめ】\n局所進行例に対しては同時併用化学療法や組織内照射が行われ治療強度は高められていたが, 重篤な有害反応の発症はなかった. 今後さらなる経過観察が必要である.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線腫瘍学会第２１回学術大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長谷川, 正俊"}],"nameIdentifiers":[{"nameIdentifier":"621834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野, 達也"}],"nameIdentifiers":[{"nameIdentifier":"621835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田巻, 倫明"}],"nameIdentifiers":[{"nameIdentifier":"621836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"浅川, 勇雄"}],"nameIdentifiers":[{"nameIdentifier":"621837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"玉本, 哲朗"}],"nameIdentifiers":[{"nameIdentifier":"621838","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"片山, 絵美子"}],"nameIdentifiers":[{"nameIdentifier":"621839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田, 博司"}],"nameIdentifiers":[{"nameIdentifier":"621840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石内, 勝吾"}],"nameIdentifiers":[{"nameIdentifier":"621841","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上, 健"}],"nameIdentifiers":[{"nameIdentifier":"621842","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野, 隆史"}],"nameIdentifiers":[{"nameIdentifier":"621843","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621844","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田巻 倫明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"浅川 勇雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621846","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"玉本 哲郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621847","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石内 勝吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621848","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上 健","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621849","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野 隆史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621850","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"重イオン線照射によるアポトーシス誘発に関与する遺伝子発現の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"重イオン線照射によるアポトーシス誘発に関与する遺伝子発現の検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-01-16"},"publish_date":"2009-01-16","publish_status":"0","recid":"62947","relation_version_is_last":true,"title":["重イオン線照射によるアポトーシス誘発に関与する遺伝子発現の検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:24:55.501138+00:00"}