{"created":"2023-05-15T14:46:04.530608+00:00","id":62940,"links":{},"metadata":{"_buckets":{"deposit":"abd639b7-a074-40f3-a1ba-74a2f7aac29c"},"_deposit":{"created_by":1,"id":"62940","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62940"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062940","sets":["10:29"]},"author_link":["621762","621757","621756","621767","621769","621760","621765","621758","621768","621763","621764","621754","621766","621759","621761","621755"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-26","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】新規リガンド[18F]FE-SPA-RQを用いて脳内NK1受容体の定量を行った。\n【方法】男性健常者7名を対象に、[18F]FE-SPA-RQ静注後より330分後までのPET測定を行った。血液入力関数を用いた動態解析により受容体結合能を求め、小脳を参照領域としたsimplified reference tissue model (SRTM)およびratio methodによる結合能と比較した。\n【結果】動態解析による結合能は尾条核3.15±0.36、被核3.11±0.66、海馬傍回1.17±0.25、後頭葉0.94±0.23、側頭葉0.82±0.15、前頭葉0.76±0.15、前部帯状回0.69±0.16、視床0.46 ± 0.14であり、SRTMおよびratio methodによる結合能と良好な相関を示した(r=0.94-0.98)。\n【考察】[18F]FE-SPA-RQにより脳内NK1の定量が可能であった。また、動脈採血および長時間のPET測定が不要なratio methodの妥当性が示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第48回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"奥村, 正紀"}],"nameIdentifiers":[{"nameIdentifier":"621754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川, 亮介"}],"nameIdentifiers":[{"nameIdentifier":"621755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"621756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋, 英彦"}],"nameIdentifiers":[{"nameIdentifier":"621757","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"621758","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"621759","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保, 善朗"}],"nameIdentifiers":[{"nameIdentifier":"621760","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"621761","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥村 正紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621762","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川 亮介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621763","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621764","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 英彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621765","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621766","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621767","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 善朗","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621768","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621769","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[18F]FE-SPA-RQによる脳内NK1受容体の定量","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[18F]FE-SPA-RQによる脳内NK1受容体の定量"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-01-07"},"publish_date":"2009-01-07","publish_status":"0","recid":"62940","relation_version_is_last":true,"title":["[18F]FE-SPA-RQによる脳内NK1受容体の定量"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:25:00.309064+00:00"}