{"created":"2023-05-15T14:46:03.097628+00:00","id":62908,"links":{},"metadata":{"_buckets":{"deposit":"9a5e287b-4350-456d-9a93-94bf9ba823e6"},"_deposit":{"created_by":1,"id":"62908","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62908"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062908","sets":["10:29"]},"author_link":["621408","621426","621410","621421","621417","621425","621418","621414","621422","621409","621412","621415","621416","621419","621413","621420","621423","621424","621411","621407"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-11-21","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ミスマッチ修復は、複製時における塩基のミスマッチを修復し、点突然変異やフレームシフト突然変異を抑制する。その欠損は、複製時エラーを増大させ、HNPCCや小児のリンパ腫の原因となる。本研究では、ミスマッチ修復の重要な構成成分のMlh1遺伝子のノックアウトマウスを用いて、放射線が修復エラーにどのように関与するかを検討した。生後２週、１０週のマウスに2GyのＸ線を全身照射し、その後発生した胸腺リンパ腫のIkaros遺伝子の突然変異頻度並びにスペクトラムを、非照射群に発生したリンパ腫と比較した。その結果、ほとんどのリンパ腫において、リピート配列にフレームシフト変異が入ることによりIkarosタンパクをつくられていないことが明らかとなった。特に、Ｘ線誘発のリンパ腫では、１つのリンパ腫に複数のフレームシフトが存在するもの、点突然変異が加わっているものが多数存在し、複製エラーが増加していることが示唆された。おそらく、放射線の役割の一つは細胞死を誘発し、その回復に急激な分裂を誘発することであると考えられる。実際、Mlh1マウスに、人為的に大腸炎を誘発し、大腸の組織修復を促すだけで、大腸がんの発生率が増大することを確認している。放射線は、ミスマッチ修復に欠損のある条件下で、複製エラーを間接的に誘発することで発がんを促進すると結論した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第51回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島田, 義也"}],"nameIdentifiers":[{"nameIdentifier":"621407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小玉, 陽太郎"}],"nameIdentifiers":[{"nameIdentifier":"621408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中田, 章史"}],"nameIdentifiers":[{"nameIdentifier":"621409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今村, 智子"}],"nameIdentifiers":[{"nameIdentifier":"621410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋, 江里佳"}],"nameIdentifiers":[{"nameIdentifier":"621411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝本, 美咲"}],"nameIdentifiers":[{"nameIdentifier":"621412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡, 達彦"}],"nameIdentifiers":[{"nameIdentifier":"621413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村, まゆみ"}],"nameIdentifiers":[{"nameIdentifier":"621414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 光明"}],"nameIdentifiers":[{"nameIdentifier":"621415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼, 志津子"}],"nameIdentifiers":[{"nameIdentifier":"621416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小玉 陽太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中田 章史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今村 智子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 江里佳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝本 美咲","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 光明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621425","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621426","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ミスマッチ修復欠損マウスにおける放射線発がんの特徴","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミスマッチ修復欠損マウスにおける放射線発がんの特徴"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-12-09"},"publish_date":"2008-12-09","publish_status":"0","recid":"62908","relation_version_is_last":true,"title":["ミスマッチ修復欠損マウスにおける放射線発がんの特徴"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:25:22.511889+00:00"}