{"created":"2023-05-15T14:46:01.351636+00:00","id":62869,"links":{},"metadata":{"_buckets":{"deposit":"d4d51e9f-a5b0-4665-901e-43be20425b15"},"_deposit":{"created_by":1,"id":"62869","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62869"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062869","sets":["10:29"]},"author_link":["621013","621025","621014","621020","621027","621017","621026","621023","621015","621019","621018","621021","621016","621024","621022"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-11-21","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"野生型CHO細胞とそのNHEJ修復欠損型xrs6細胞のX線による致死を指標に、OHラジカル由来の間接作用と直接作用の寄与率をDMSO濃度無限大での保護率から算出した。2Gy照射時のそれぞれの細胞生存率は39％と1％であり、間接作用による細胞致死分画は47％と49％、直接作用によるものは14％と50％であった。間接作用による部分に大きな差がないことは、間接作用による損傷の修復にはNHEJがあまり寄与しないのかもしれない。また直接作用による細胞致死がxrs6細胞では3倍以上(<50/14)も増加しているが、これはNHEJにより修復可能なDSBが修復されずに致死損傷となったためと考えられる。またこの事からxrs6細胞のX線高感受性の原因は、NHEJにより本来修復される直接作用由来のDSBが修復されなかったためと推測される。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第51回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平山, 亮一"}],"nameIdentifiers":[{"nameIdentifier":"621013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤, 佳也"}],"nameIdentifiers":[{"nameIdentifier":"621014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 敦"}],"nameIdentifiers":[{"nameIdentifier":"621015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野口, 実穂"}],"nameIdentifiers":[{"nameIdentifier":"621016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 孔貴"}],"nameIdentifiers":[{"nameIdentifier":"621017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤, 玲子"}],"nameIdentifiers":[{"nameIdentifier":"621018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 興一"}],"nameIdentifiers":[{"nameIdentifier":"621019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安, 隆一"}],"nameIdentifiers":[{"nameIdentifier":"621020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 敦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 孔貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤 玲子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621026","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"621027","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"NHEJ修復欠損xrs6細胞における放射線作用の細胞致死効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NHEJ修復欠損xrs6細胞における放射線作用の細胞致死効果"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-11-25"},"publish_date":"2008-11-25","publish_status":"0","recid":"62869","relation_version_is_last":true,"title":["NHEJ修復欠損xrs6細胞における放射線作用の細胞致死効果"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:25:49.293867+00:00"}