{"created":"2023-05-15T14:46:00.239994+00:00","id":62844,"links":{},"metadata":{"_buckets":{"deposit":"3681ef50-1a4c-45aa-9120-e8c86b9fc1a1"},"_deposit":{"created_by":1,"id":"62844","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62844"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062844","sets":["10:29"]},"author_link":["620784","620769","620768","620775","620782","620774","620773","620772","620778","620776","620765","620771","620779","620783","620777","620781","620770","620780","620767","620766"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-11-07","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】アルツハイマー病（Alzheimer's disease: AD）、軽度認知障害（Mild cognitive impairment: MCI）、健常高齢者において脳内アミロイド沈着と認知機能の経時的変化を測定する。【対象・方法】健常高齢者6例（62~72歳）、MCI 5例（71~80歳）、AD 5例（55~76歳）。〔11C〕PIB PET静注後90分間脳内放射能を測定し、血漿入力関数を用いてLogan plot解析にて分布容積比を算出し、脳内アミロイド結合の指標とした。PET検査と同時に頭部MRI、認知機能検査を行った。平均追跡期間22.3±4.2ヶ月で二回目の検査を行い、経過前後で比較検討した。【結果・結論】MCI 5例中1例に大脳皮質全体で約12％程度の脳内アミロイド沈着の経時的な増加が認められ、特に楔前部において増加率は約40％程度であり、最大であった。他のAD 5例、健常者高齢者6例では明らかな増加は認められなかった。また脳内アミロイド結合の増加したMCI 1症例において頭部MRIにて海馬傍回の萎縮が進行し（VSRAD Z score  1.81→2.44）、認知機能障害の進行が認められ（MMSE 27→20点、FAB 17→16点、CDR 0.5→1）、経過中にADへconversionしたと考えられた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第20回日本脳循環代謝学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三好, 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常嘉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620784","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"〔11C〕PIB PETによる脳内アミロイド沈着と認知機能の経時変化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〔11C〕PIB PETによる脳内アミロイド沈着と認知機能の経時変化"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-11-07"},"publish_date":"2008-11-07","publish_status":"0","recid":"62844","relation_version_is_last":true,"title":["〔11C〕PIB PETによる脳内アミロイド沈着と認知機能の経時変化"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:26:06.110065+00:00"}