@misc{oai:repo.qst.go.jp:00062837,
 author = {岩川, 眞由美 and 古田, 玲子 and 大野, 達也 and 石川, 顕一 and 加藤, 真吾 and 辻井, 博彦 and 北川, 知行 and 今井, 高志 and 岩川 眞由美 and 大野 達也 and 石川 顕一 and 加藤 眞吾 and 辻井 博彦 and 今井 高志},
 month = {Oct},
 note = {Vil1, a marker for cervical adenocarcinoma, found by integrated analysis for chromosomal structure and expression.
\nMayumi Iwakawa a, Reiko Furuta b, Tatsuya Ohno a, Ken-ichi Ishikawa a, Shingo Kato a, Tomoaki Tamaki a, Hirohiko Tsujii a, Tomoyuki Kitagawa b and Takashi Imai a  
\naResearch Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, 
b Department of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan
\n
Objective: Cervical adenocarcinomas (AD) are increasing in incidence each year. However, the Pap smear screening test for dignosis of squamous cell carcinoma (SCC) is more likely to fail diagnosis of AD. The aim of this study was to identify a molecular biomarker for AD.
Study design: 97 cervical cancer patients (65 SCC, 32 AD) were enrolled in this study. ArrayCGH and microarray expression analysis for biopsy samples screened the genes responsible for differntial carcinogenesis between AD and SCC. 
Results: We first identified common deletious region in 2q33-ter for SCCs by aCGH analysis. Among genes mapped in this region, expression of Vil1 was repressed in SCC and up-regulated in AD in microarray analysis. In Q-PCR analysis, no deletion was found in 14 AD (44%). Immunostaining for Vil1, which was negative in normal uterine cervix, for 71 samples (45 SCC, 26 AD) revealed 7 positive cases and all these 7 were AD. Along with these analyses, HPV infections, p53 status, and p16 expression were investigated to elucidate their effects on carcinogenesis. 
Conclusion: Vil1, encoding a actin-binding protein, is a possible diagnostic marker of cervical AD., 第67回日本癌学会学術総会},
 title = {染色体構造と遺伝子発現解析により同定した子宮頸部腺癌診断マーカー、Vil1},
 year = {2008}
}