{"created":"2023-05-15T14:45:58.936596+00:00","id":62815,"links":{},"metadata":{"_buckets":{"deposit":"2e66c3b2-b114-4070-95ce-75daaf2e2fe8"},"_deposit":{"created_by":1,"id":"62815","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62815"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062815","sets":["10:29"]},"author_link":["620450","620451","620452","620456","620449","620454","620459","620445","620447","620458","620448","620460","620457","620446","620455","620444","620443","620453"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-26","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Yokoiらによって開発されたグラフプロット法（J Nucl Med,1993）ではX軸に組織放射能濃度積分値/入力関数積分値を、Y軸に組織放射能濃度/入力関数積分値をプロットし、２コンパートメントモデル（2CM)に従うトレーサーではプロットは直線となり、X軸切片が分布容積値にY軸切片がK1値になる。本研究ではこのプロット法を3CMに従うトレーサーであるドーパミンD2受容体リガンドのC-11-FLB457に適用し、非特異的分布容積（Vn)、総分布容積（Vt)、受容体結合能（BP)の計算を試みた。プロットは原点側に凸の曲線となり、プロットの早期の部分の直線回帰によりK1およびVnを、後期の部分よりVtを求め、これらによりBPを計算した。K1およびVｔは非線刑最少二乗法による値とよく一致したが、Vnでは統計的な過大評価が、BPでは過小評価がみられた。本プロット法はトレーサーの動態を視覚的に理解するのに適しており、新規の放射性リガンドの動態解析に有用である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第48回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"620443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"620444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原, 美保"}],"nameIdentifiers":[{"nameIdentifier":"620445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"620446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋, 英彦"}],"nameIdentifiers":[{"nameIdentifier":"620447","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"620448","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 裕一"}],"nameIdentifiers":[{"nameIdentifier":"620449","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"620450","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横井, 孝司"}],"nameIdentifiers":[{"nameIdentifier":"620451","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620452","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原 美保","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 英彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横井 孝司","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620460","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"新しいグラフプロット法による脳神経受容体結合能の定量解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新しいグラフプロット法による脳神経受容体結合能の定量解析"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-28"},"publish_date":"2008-10-28","publish_status":"0","recid":"62815","relation_version_is_last":true,"title":["新しいグラフプロット法による脳神経受容体結合能の定量解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:26:25.670791+00:00"}