{"created":"2023-05-15T14:45:57.046729+00:00","id":62773,"links":{},"metadata":{"_buckets":{"deposit":"7037e113-8914-422d-ae7b-f9a94a1e83f8"},"_deposit":{"created_by":1,"id":"62773","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62773"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062773","sets":["10:29"]},"author_link":["619971","619975","619979","619976","619980","619966","619969","619973","619972","619974","619977","619981","619968","619978","619970","619967"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-03-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Exposure of sublethal doses of ionizing radiation can induce\nprotective mecanisms against a subsequent higher dose irradiation.\nThis phenomenon, called radiation-induced adaptive response (AR), has\nbeen described in a wide range of biological models, both in vitro and\nin vivo. We previously demonstrated the existence of AR in mice during\nlate organogenesis. For better understanding of molecular mechanisms\nunderlying AR in this model, we performed a global analysis of\ntranscriptome regulations in cells collected from whole mouse fetuses,\nafter in utero exposure to priming irradiation. Several combinations\nof radiation dose and dose-rate were applied to induce or not an AR in\nour system. Expression levels of 14000 different genes 24 hours after\nirradiation were measured. While many genes were not modulated at all\nafter radiation exposure and 166 genes were deregulated for all\nconditions, we identified a panel of 861 genes (so called \"AR genes\")\nshowing significantly different expression ratios under AR-inducing\nand non AR-inducing conditions. A sub-list of 119 AR genes (so-called\nARS genes) with higher discriminative characteristics was also\ncreated. We assessed the proportion of total and AR genes involved in\nvarious molecular pathways and the number of these genes for each of\nthe GO terms. Gene enrichment analysis revealed that growth factor,\ntranslation or metallopeptidase activities (among others) were\npotential targets for our study. Since AR genes were involved in a\nvariety of functions and cellular processes, we applied a functional\nclassification algorithm which clustered genes in a limited number of\nfunctionally related groups. Our results emphasized the role of signal\ntransduction mechanisms in the induction of AR (one-third of AR genes\nwere directly involved in cell signaling). Previous investigations\nsuggested the crucial role of p53 in cells's response to radiation and\npotentially AR; we observed that a significant proportion of AR genes\nwere p53-related or possessed p53-binding sites. Furthermore, many AR\ngenes were important for fetal development, like growth factors or\ngenes involved in signaling cascades (CK2 ...). Taken together, our\nresults present the first evidence of molecular mechanisms modulation\nby AR in utero, which may have potentially important consequences for\nfurther developmental processes, and could even influence\ntumorigenesis. The late effects occuring in mice adapted in utero,\nsuch as chromosomal aberrations or cancer initiation) therefore are a\npromising and interesting area for further research.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"NIRS International Symposium on Visualization of Radiation Response at the Molecular and Cellular Levels","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{"nameIdentifier":"619966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"619967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shang, Yi"}],"nameIdentifiers":[{"nameIdentifier":"619968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohyama, Harumi"}],"nameIdentifiers":[{"nameIdentifier":"619969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"619970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo"}],"nameIdentifiers":[{"nameIdentifier":"619971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"619972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayata, Isamu"}],"nameIdentifiers":[{"nameIdentifier":"619973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚 奕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大山 ハルミ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 徹夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早田 勇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619981","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"On radiation-induced adaptive response in fetal mice: I.. A comparative microarray analysis of gene expressions in mouse fetuses","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"On radiation-induced adaptive response in fetal mice: I.. A comparative microarray analysis of gene expressions in mouse fetuses"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-09"},"publish_date":"2008-10-09","publish_status":"0","recid":"62773","relation_version_is_last":true,"title":["On radiation-induced adaptive response in fetal mice: I.. A comparative microarray analysis of gene expressions in mouse fetuses"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:26:56.880324+00:00"}