@misc{oai:repo.qst.go.jp:00062773,
 author = {Vares, Guillaume and Bing, Wang and Shang, Yi and Ohyama, Harumi and Tanaka, Kaoru and Nakajima, Tetsuo and Nenoi, Mitsuru and Hayata, Isamu and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 王 冰 and 尚 奕 and 大山 ハルミ and 田中 薫 and 中島 徹夫 and 根井 充 and 早田 勇},
 month = {Mar},
 note = {Exposure of sublethal doses of ionizing radiation can induce
protective mecanisms against a subsequent higher dose irradiation.
This phenomenon, called radiation-induced adaptive response (AR), has
been described in a wide range of biological models, both in vitro and
in vivo. We previously demonstrated the existence of AR in mice during
late organogenesis. For better understanding of molecular mechanisms
underlying AR in this model, we performed a global analysis of
transcriptome regulations in cells collected from whole mouse fetuses,
after in utero exposure to priming irradiation. Several combinations
of radiation dose and dose-rate were applied to induce or not an AR in
our system. Expression levels of 14000 different genes 24 hours after
irradiation were measured. While many genes were not modulated at all
after radiation exposure and 166 genes were deregulated for all
conditions, we identified a panel of 861 genes (so called "AR genes")
showing significantly different expression ratios under AR-inducing
and non AR-inducing conditions. A sub-list of 119 AR genes (so-called
ARS genes) with higher discriminative characteristics was also
created. We assessed the proportion of total and AR genes involved in
various molecular pathways and the number of these genes for each of
the GO terms. Gene enrichment analysis revealed that growth factor,
translation or metallopeptidase activities (among others) were
potential targets for our study. Since AR genes were involved in a
variety of functions and cellular processes, we applied a functional
classification algorithm which clustered genes in a limited number of
functionally related groups. Our results emphasized the role of signal
transduction mechanisms in the induction of AR (one-third of AR genes
were directly involved in cell signaling). Previous investigations
suggested the crucial role of p53 in cells's response to radiation and
potentially AR; we observed that a significant proportion of AR genes
were p53-related or possessed p53-binding sites. Furthermore, many AR
genes were important for fetal development, like growth factors or
genes involved in signaling cascades (CK2 ...). Taken together, our
results present the first evidence of molecular mechanisms modulation
by AR in utero, which may have potentially important consequences for
further developmental processes, and could even influence
tumorigenesis. The late effects occuring in mice adapted in utero,
such as chromosomal aberrations or cancer initiation) therefore are a
promising and interesting area for further research., NIRS International Symposium on Visualization of Radiation Response at the Molecular and Cellular Levels},
 title = {On radiation-induced adaptive response in fetal mice: I.. A comparative microarray analysis of gene expressions in mouse fetuses},
 year = {2007}
}