@misc{oai:repo.qst.go.jp:00062670,
 author = {Miyoshi, Michie and Shinoto, Hitoshi and Sato, Koichi and Tanaka, Noriko and Fukushi, Kiyoshi and Ito, Hiroshi and Suhara, Tetsuya and Irie, Toshiaki and et.al and 三好 美智恵 and 篠遠 仁 and 佐藤 康一 and 田中 典子 and 福士 清 and 伊藤 浩 and 須原 哲也 and 入江 俊章},
 month = {Jul},
 note = {Background and aims: Deposits of beta-amyloid plaques in the brain are one of the most characteristic neuropathological changes of Alzheimers disease (AD). Carbon-11 labeled Pittsburgh Compound-B (PIB) is widely used as a radiotracer for positron emission tomography (PET) to estimate the beta-amyloid deposition in vivo. In this study, we investigated changes in beta-amyloid deposition during about 2 years in patients with AD and mild cognitive impairment (MCI), and healthy volunteers (HV) by PET. Methods: Two patients with AD (58-73 years of age; male/female: 1/1; MMSE: 19), 4 with MCI (70-80 years; male/female: 3/1; MMSE: 25-27) and age-matched 2 HV (63-66 years; male/female: 0/2; MMSE: 29-30) participated in this study. Twice PET studies were performed on all subjects with an interval of 1.8 +/- 0.4 years (mean+/-SD). All AD patients were treated with cholinesterase inhibitor at the time of second PET study, while all MCI patients had not been given any medicine. Two MCI patients had converted to AD at the time of second PET study and one of them had started to be treated with cholinesterase inhibitor. After intravenous injection of [11C]PIB (about 370 MBq), a dynamic PET scan was performed for 90min with arterial blood sampling. All PET images were normalized to the MNI space using SPM. Distribution volume ratios (DVR), indicating the retention of [11C]PIB, were calculated on a voxel-by-voxel basis by Logan graphical analysis with the use of cerebellum as a reference brain region. Regions of interest (ROI) were drawn on the DVR images. RESULTS: Increase in DVR of [11C]PIB of 27-43% in the cerebral cortex during interval period of two PET, International Conference on Alzheimer's Disease 2008},
 title = {Changes in beta-amyloid deposition in Alzheimers disease and mild cognitive impairment measured by PET with [11C]-PIB: Two years follow up study},
 year = {2008}
}