@misc{oai:repo.qst.go.jp:00062669,
 author = {Shimada, Hitoshi and Shinoto, Hitoshi and Hirano, Shigeki and Miyoshi, Michie and Sato, Koichi and Tanaka, Noriko and Ota, Miho and Fukushi, Kiyoshi and Suhara, Tetsuya and Hattori, Takamichi and Irie, Toshiaki and 島田 斉 and 篠遠 仁 and 平野 成樹 and 三好 美智恵 and 佐藤 康一 and 太田 深秀 and 福士 清 and 須原 哲也 and 入江 俊章},
 month = {Jul},
 note = {Background:
Patients with Alzheimers disease (AD) show parahippocampal atrophy and amyloid deposition mainly in cerebral cortex. We investigated the correlation between parahippocampal atrophy assessed by using voxel-based morphometry and amyloid deposition estimated by [11C]PIB-PET.
Methods:
Participants were 12 patients with AD, 11 patients with mild cognitive impairment (MCI) and 17 healthy controls. We estimated the distribution volume ratio (DVR) using Logan graphical analysis. We also performed VBM analysis using spm5 for each MR images and assessed Z scores of hippocampal volumes by VOI analysis.
Results:
Weak positive correlation between DVRs of [11C]PIB-PET and parahippocampal Z scores estimated by VBM analysis were shown (r=0. 39, p<0.05). As to two cases of patients with early-onset AD, however, Z scores of parahippocampal area were almost normal and cortical DVRs were high. Moreover, Z scores of parahippocampal area were high and cortical DVRs were not abnormally high.
Conclusions:
Weak positive correlation between cortical amyloid deposition and parahippocampal atrophy were shown, International Conferenece on Alzheimer's Disease 2008},
 title = {The deadline for this submission has passed.No further editiong is possible.},
 year = {2008}
}