@misc{oai:repo.qst.go.jp:00062487,
 author = {Hasegawa, Azusa and Mizoe, Junetsu and Takagi, Ryo and Bessho, Hiroki and Onda, Takeshi and Tsujii, Hirohiko and 長谷川 安都佐 and 溝江 純悦 and 高木 亮 and 別所 央城 and 恩田 健志 and 辻井 博彦},
 month = {Mar},
 note = {Purpose: To estimate the toxicity and efficacy of carbon ion radiotherapy for skull base and paracervical tumors.
Materials and Methods: Between April 1997 and August 2007, a total of 46 patients with skull base or paracervical tumors have been treated with carbon ion radiotherapy for the phase I/II or phase II clinical trials.  The 46 patients consisting of 20 males and 26 females, their age range was from 16 to 78, with a median age of 50 years.  Histologically, 46 patients had 29 chordoma, 6 malignant meningioma, 7 chondrosarcoma, 3 olfactory neuroblastoma and one giant cell sarcoma.
Results: Median follow-up time in 46 patients was 50 months (range, 4-122 months).  At the time of analysis, there was no evidence of any serious acute or late reactions.  The five-year local control rates according to prescribed tumor dose were 75% at 48 GyE (n=4), 67% at 52.8 GyE (n=6), 78% at 57.6 GyE (n=9) and 93% at 60.8 GE (n=27), respectively.  The five-year overall survival rates were 50% at 48 GyE, 100% at 52.8 GyE, 100% at 57.6 GyE and 76% at 60.8 GyE, respectively.  In 29 chordoma patients, they were divided into two groups; a low-dose group (n=10) irradiated with doses ranging from 48 to 57.8 GyE and a high-dose group (n=19) irradiated with a 60.8 GyE. The five-year local control rates were 60% for the low-dose group and 91% for the high-dose group.  The five-year overall survival rates were 89% for the low-dose group and 94% for the high-dose group. 
Conclusions: Carbon ion radiotherapy will deliver a high local control rates with low toxicity to the surrounding normal tissues., NIRS-MD Anderson　Ｓｙｍｐｏｓｉｕｍ　ｏｎ　Ｃｌｉｎｉｃａｌ　ｌｓｓｕｅｓ　ｆｏｒ　Ｐａｒｔｉｃｌｅ　Ｔｈｅｒａｐｙ},
 title = {Carbon Ion Radiotherapy for Skull Base and Paracervical Tumors},
 year = {2008}
}