@misc{oai:repo.qst.go.jp:00062484,
 author = {Iwakawa, Mayumi and Imai, Takashi and 岩川 眞由美 and 今井 高志},
 month = {Mar},
 note = {To determine the genetic characteristics of individual patients and their cancers for more effective radiotherapy, we have studied genetic variations associated with individual radiosensitivity and gene expression of tumors with different radiosensitivity. First, as an experimental model, we subjected 276 second filial generation (F2) mice descended from two inbred mouse strains, radiation-sensitive C57BL/6J (B6) and radiation-resistant C3H/HeMs (C3H), to whole-body irradiation of 2.5 Gy. The largest difference in jejunal crypt apoptosis values was observed between the B6 and C3H strains. ASI values in B6 and C3H mice were 97.7 +- 32.9 and 49.0 +- 24.9, respectively. We selected SNP markers, where alleles between B6 and C3H were different, at 20-Mb intervals on the chromosomes. Genome-wide analysis revealed 8 QTLs (2 on chromosome 9, 4 on 15, 1 on 17, and 1 on 18) with log odds (LOD) scores ranging from 2.11 to 3.91. We found a significant locus on chromosome 15. Second, in clinical setting, DNA was sampled from 399 Japanese breast cancer patients who qualified for breast-conserving radiotherapy. A total of 999 single nucleotide polymorphisms from 137 candidate genes for radiation susceptibility were genotyped, and the global haplotype association indicated that estimated haplotypes in five loci, RAD9A, PTTG1, LIG3, CD44, and MAD2L2 genes, were associated with early adverse skin reaction risk. In addition, to contribute to the fundamental knowledge for selection of treatment modalities to achieve personalized radiotherapy, data from a murine model for biological effectiveness specific to carbon-ion radiotherapy should be presented., NIRS-MD Anderson Symposium on Clinical Issues for Particle Therapy},
 title = {Genetic Variation and Radiosensitivity : towards an Individualized Radiation Therapy},
 year = {2008}
}