{"created":"2023-05-15T14:45:43.040500+00:00","id":62463,"links":{},"metadata":{"_buckets":{"deposit":"033bae70-7983-4973-a002-16826a438394"},"_deposit":{"created_by":1,"id":"62463","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62463"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062463","sets":["10:29"]},"author_link":["617186","617179","617189","617181","617188","617176","617190","617180","617177","617182","617183","617178","617174","617185","617184","617187","617175"],"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高エネルギーＸ線と薬品送達システム(Drug Delivery System)とを組み\n合わせたＸ線DDSのための薬剤として、重金属元素を含有したDDS薬剤が注目されてい\nる。キャリアと呼ばれる高分子ミセルに含有された薬剤は徐々に放出されるが、細胞\nに取り込まれているかどうかを確認することは難しい。そこで、PIXE（Particle\nInduced X-ray Emissions Analysis）分析法と、白金性抗癌剤を含むDDS薬剤（シス\nプラチンミセル）を用いて、CHO（Chinese Hamster Ovary）細胞内の白金含有量を測\n定した。その結果、DDS薬剤の状態では、普通の薬剤に比べて、細胞への取込みが\n1/10程度と低いことを確認した。PIXEを用いたDDS薬剤の性能評価について発表す\nる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第9回化学放射線治療科学研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"水野, 和恵"}],"nameIdentifiers":[{"nameIdentifier":"617174","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 梓"}],"nameIdentifiers":[{"nameIdentifier":"617175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遊佐, 訓孝"}],"nameIdentifiers":[{"nameIdentifier":"617176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西, 輝昭"}],"nameIdentifiers":[{"nameIdentifier":"617177","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"濱野, 毅"}],"nameIdentifiers":[{"nameIdentifier":"617178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川, 剛弘"}],"nameIdentifiers":[{"nameIdentifier":"617179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"磯, 浩之"}],"nameIdentifiers":[{"nameIdentifier":"617180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今関, 等"}],"nameIdentifiers":[{"nameIdentifier":"617181","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上坂, 充"}],"nameIdentifiers":[{"nameIdentifier":"617182","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"水野 和恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 梓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617184","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西 輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617185","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"濱野 毅","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617186","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 剛弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617187","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"磯 浩之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617188","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今関 等","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617189","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上坂 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617190","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"PIXEによるX線DDSの細胞取り込み分析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PIXEによるX線DDSの細胞取り込み分析"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-16"},"publish_date":"2008-03-16","publish_status":"0","recid":"62463","relation_version_is_last":true,"title":["PIXEによるX線DDSの細胞取り込み分析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:30:29.903819+00:00"}