@misc{oai:repo.qst.go.jp:00062451,
 author = {Mahmoud, Abd-Elrazek Helmy Sherif and Yoshikawa, Kyosan and Hasebe, Mitsuhiko and Ishikawa, Hiroyuki and Sagou, Kenji and Tanimoto, Katsuyuki and Saga, Tsuneo and Tsujii, Hirohiko and Ｓｈｅｒｉｆ Ｍａｈｍｏｕｄ Ａｂｄ−Ｅｌｒａｚｅｋ Ｈｅｌｍｙ and 吉川 京燦 and 長谷部 充彦 and 石川 博之 and 佐合 賢治 and 谷本 克之 and 佐賀 恒夫 and 辻井 博彦},
 month = {Apr},
 note = {Bone metastases occur in up to 70% of breast or prostate cancer patients and in about 15% to 30% of other cancer patients (lung, stomach, uterus, bladder, colon, thyroid, kidney, and rectum).1 Early detection of metastatic bone disease and the definition of the extent, pattern, and aggressiveness are important prerequisites for adequate treatment by resection, radiation, or systemic therapy.2,3 Medical
imaging techniques play an important role in the assessment of these bone metastases. A wealth of historical data and clinical experience led to the establishment of the isotope bone scan as the reference standard in the search for skeletal metastatic disease. However, in malignancies, bone scans are now used less often and are not considered routine in all cases of breast or prostate cancer. Essentially, bone scans are currently used only where there is an issue regarding staging or if the patient has bone symptoms.5,6 The most commonly used tracer for skeletal imaging in general nuclear medicine is 99mTc-Methylene diphosphonate (99mTc-MDP).7 Amino acid metabolism of cancer is associated with numerous catabolic processes favoring tumor growth.8 As an essential amino acid, L-methionine plays a central role in the altered metabolism of cancer cells.9 Increased uptake of MET as measured by PET has been suggested to reflect increased transport, transmethylation rate, and protein synthesis of malignant tissue.10-12 In this study, we evaluated the role of whole body (WB) PET 11C-Methionine imaging in the detection of skeletal
metastatic lesions in comparison to bone scintigraphy being the conventional screening method for bone metastasis., 第45回千葉核医学研究会},
 title = {Whole Body Methionine PET vs. Conventional Bone Scintigraphy for Early Detection of Metastatic Bone Lesions},
 year = {2007}
}